A retrospective analysis of vinorelbine chemotherapy for patients with previously treated soft-tissue sarcomas.

A retrospective analysis of vinorelbine chemotherapy for patients with previously treated soft-tissue sarcomas. Research Abstract Details 

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A retrospective analysis of vinorelbine chemotherapy for patients with previously treated soft-tissue sarcomas. Abstract Text:

Sibyl E Anderson,Mary L Keohan,David R D'Adamo,Robert G Maki,

Introduction. The role of vinorelbine in specific soft tissue sarcoma subtypes is unclear. We present retrospective single institution experience with single-agent vinorelbine in subjects with metastatic soft tissue malignancies. Methods. Fifty-eight patients were treated with single agent intravenous vinorelbine between April 1997 and December 2004. Doxorubicin had been administered previously to 53 subjects (91%), and the median number of lines of previous chemotherapy was 3 (range 0-7). Results. Patients received a median 6 doses of vinorelbine (range 1-65). The overall response rate was 6% (3 patients: 1 angiosarcoma, 1 epithelioid sarcoma, and 1 embryonal rhabdomyosarcoma). Fourteen patients (26%) experienced a best result of stable disease. Median time to progression was 1.8 months (95% confidence intervals 1.5-2.1 months, Kaplan-Meier estimate). Eight patients experienced grade 3 or 4 toxicity, most commonly febrile neutropenia. Conclusion. Vinorelbine demonstrates limited activity in a heavily pretreated group of soft-tissue sarcoma patients. Prospective investigation may be considered for selected sarcoma subtypes.

A retrospective analysis of vinorelbine chemotherapy for patients with previously treated soft-tissue sarcomas. Publishing Authors By Initials

SE Anderson,ML Keohan,DR D'Adamo,RG Maki,

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A retrospective analysis of vinorelbine chemotherapy for patients with previously treated soft-tissue sarcomas. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Sarcoma

VOLUME: 2006

Page Numbers: 15947

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ISSN: 1357-714X

DAY: 21

MONTH: 11

YEAR: 2006

A retrospective analysis of vinorelbine chemotherapy for patients with previously treated soft-tissue sarcomas. Information

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LANGUAGE: eng

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Grant and Affiliation Information for A retrospective analysis of vinorelbine chemotherapy for patients with previously treated soft-tissue sarcomas.

AFFILIATION: Gynecological Oncology Services, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.

Country: Egypt

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MEDLINETA: Sarcoma

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