A regional cooperative clinical study of radiotherapy for cervical cancer in east and south-east Asian countries.

A regional cooperative clinical study of radiotherapy for cervical cancer in east and south-east Asian countries. Research Abstract Details 

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A regional cooperative clinical study of radiotherapy for cervical cancer in east and south-east Asian countries. Abstract Text:

Takashi Nakano,Shingo Kato,Jianping Cao,Juying Zhou,Raden Susworo,Nana Supriana,Shinichiro Sato,Tatsuya Ohno,Hisao Suto,Yuzuru Nakamura,Chul-Koo Cho,Fuad B Ismail,Miriam J C Calaguas,Rey H de Los Reyes,Yaowalak Chansilpa,Kullathom Thephamongkhol,Nguyen Ba Duc,To Anh Dung,Hirohiko Tsujii,Takashi Nakano,Shingo Kato,Jianping Cao,Juying Zhou,Raden Susworo,Nana Supriana,Shinichiro Sato,Tatsuya Ohno,Hisao Suto,Yuzuru Nakamura,Chul-Koo Cho,Fuad B Ismail,Miriam J C Calaguas,Rey H de Los Reyes,Yaowalak Chansilpa,Kullathom Thephamongkhol,Nguyen Ba Duc,To Anh Dung,Hirohiko Tsujii,

PURPOSE: Radiotherapy differed widely in east and south-east Asia because of technical, cultural, and socio-economic differences. With the purpose of standardizing radiotherapy for cervical cancer in the region, an international clinical study was conducted. MATERIALS AND METHODS: Eleven institutions in eight Asian countries participated in the study. Between 1996 and 1998, 210 patients with stage IIIB cervical cancer were enrolled. Patients were treated with a combination of external beam radiotherapy (total dose, 50Gy) and either high-dose-rate (HDR) or low-dose-rate (LDR) intracavitary brachytherapy (ICBT) according to the institutional practice. The planned point A dose was 20-28Gy/4 fractions for HDR-ICBT and 30-40Gy/1-2 fractions for LDR-ICBT. RESULTS: Hundred patients were treated with HDR-ICBT and 110 were treated with LDR-ICBT. The ICBT doses actually delivered to point A ranged widely: 12-32Gy in the HDR group and 26-52.7Gy in the LDR group. The 5-year follow-up rate among the countries differed greatly, from 29% to 100%. The 5-year major complication rates were 6% in the HDR group and 10% in the LDR group. The 5-year overall survival rates were 51.1% in the HDR group and 57.5% in the LDR group. CONCLUSIONS: Although there were several problems with treatment compliance and patients' follow-up, the study suggests that the protocols provided favorable outcomes with acceptable rates of late complications in the treatment of advanced cervical cancer in east and south-east Asia.

A regional cooperative clinical study of radiotherapy for cervical cancer in east and south-east Asian countries. Publishing Authors By Initials

T Nakano,S Kato,J Cao,J Zhou,R Susworo,N Supriana,S Sato,T Ohno,H Suto,Y Nakamura,CK Cho,FB Ismail,MJ Calaguas,RH de Los Reyes,Y Chansilpa,K Thephamongkhol,NB Duc,TA Dung,H Tsujii,T Nakano,S Kato,J Cao,J Zhou,R Susworo,N Supriana,S Sato,T Ohno,H Suto,Y Nakamura,CK Cho,FB Ismail,MJ Calaguas,RH de Los Reyes,Y Chansilpa,K Thephamongkhol,NB Duc,TA Dung,H Tsujii,

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A regional cooperative clinical study of radiotherapy for cervical cancer in east and south-east Asian countries. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Radiotherapy and oncology : journal of the Europea

VOLUME: 84

Page Numbers: 314-9

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ISSN: 0167-8140

DAY: 29

MONTH: 05

YEAR: 2007

A regional cooperative clinical study of radiotherapy for cervical cancer in east and south-east Asian countries. Information

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LANGUAGE: eng

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AFFILIATION: Department of Radiology and Radiation Oncology, Gunma University Graduate School of Medicine, Japan.

Country: Ireland

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MEDLINETA: Radiother Oncol

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