A recurrent craniopharyngioma illustrates the potential usefulness of urinary matrix metalloproteinases as noninvasive biomarkers: case report.

A recurrent craniopharyngioma illustrates the potential usefulness of urinary matrix metalloproteinases as noninvasive biomarkers: case report. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

A recurrent craniopharyngioma illustrates the potential usefulness of urinary matrix metalloproteinases as noninvasive biomarkers: case report. Abstract Text:

Edward R Smith,Michael Manfredi,R Michael Scott,Peter M Black,Marsha A Moses,

OBJECTIVE: Matrix metalloproteinases (MMPs) are a class of enzymes involved in angiogenesis, tumor growth, and metastasis. Recent reports indicate that urinary MMPs predict the presence of several types of tumors, including those of the breast, prostate, and bladder. Ongoing protocols at our institution are evaluating the efficacy of urinary MMPs as diagnostic markers for brain tumors and gastrointestinal disease. CLINICAL PRESENTATION: An 8-year-old girl underwent transsphenoidal resection of a craniopharyngioma at the age of 6 years with radiographic gross total resection. Two years later, her urine was analyzed for MMPs as part of an evaluation for gastrointestinal complaints. Despite normal gastrointestinal evaluation results, her urinary MMP levels were markedly elevated. She subsequently sought treatment for recurrent craniopharyngioma. INTERVENTION: The craniopharyngioma was resected again. Approximately 1 year after surgery, no sources of the elevated MMPs have been found other than the recurrent craniopharyngioma. Follow-up analysis of urinary MMPs demonstrated clearing of markers concordant with tumor treatment. CONCLUSION: We report the finding of elevated urinary MMPs in the setting of a recurrent craniopharyngioma. These biomarkers correlate with the presence of disease, clear with treatment, and can be tracked from source tissue to urine. The findings of this case support the hypothesis that urinary MMPs may be a useful predictor of the presence or recurrence of brain tumors. To our knowledge, this is the first report supporting the proof-of-principle concept that urinary MMPs may have potential usefulness in predicting the presence of brain tumors, expanding the spectrum of tumors capable of being diagnosed with this technique.

A recurrent craniopharyngioma illustrates the potential usefulness of urinary matrix metalloproteinases as noninvasive biomarkers: case report. Publishing Authors By Initials

ER Smith,M Manfredi,RM Scott,PM Black,MA Moses,

For similar neoplasms: neoplasms by site: endocrine gland neoplasms: pituitary neoplasms research abstracts see: neoplasms: neoplasms by site: endocrine gland neoplasms: pituitary neoplasms research

PUBMED ID PMID:

MEDLINE DATE:

A recurrent craniopharyngioma illustrates the potential usefulness of urinary matrix metalloproteinases as noninvasive biomarkers: case report. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Neurosurgery

VOLUME: 60

Page Numbers: E1148-9; discussion E1149

Journal Abbreviation: Neurosurgery

ISSN: 1524-4040

DAY: 3

MONTH: Jun

YEAR: 2007

A recurrent craniopharyngioma illustrates the potential usefulness of urinary matrix metalloproteinases as noninvasive biomarkers: case report. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7802914

A recurrent craniopharyngioma illustrates the potential usefulness of urinary matrix metalloproteinases as noninvasive biomarkers: case report. Keywords Mesh Terms:

KEYWORDS: Pituitary Neoplasms

MESH TERMS: surgery

Chemical & Substance for Abstract: A recurrent craniopharyngioma illustrates the potential usefulness of urinary matrix metalloproteinases as noninvasive biomarkers: case report. Information

Substance Name: Matrix Metalloproteinases

Registry Number: EC 3.4.24.-

Grant and Affiliation Information for A recurrent craniopharyngioma illustrates the potential usefulness of urinary matrix metalloproteinases as noninvasive biomarkers: case report.

AFFILIATION: Vascular Biology Program, Department of Neurosurgery, Children's Hospital Boston, and Harvard Medical School, Boston, Massachusetts 02115-5737, USA.

Country: United States

AGENCY: United States NCI

GRANT: P01CA45548

ACRONYM: CA

MEDLINETA: Neurosurgery

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

A recurrent craniopharyngioma illustrates the potential usefulness of urinary matrix metalloproteinases as noninvasive biomarkers: case report Related Publications

• A nested case-control study of sexual practices and risk factors for prevalent HIV-1 infection among young men in Kisumu, Kenya.
• A recurrent craniopharyngioma illustrates the potential usefulness of urinary matrix metalloproteinases as noninvasive biomarkers: case report.
• A simplified apparatus for photometric analysis and photomicrography.
• A tale of two proteins: differential roles and regulation of Smad2 and Smad3 in TGF-beta signaling.
• Acute parent artery dissection as a complication of mesenteric endovascular coil embolisation for pancreatic pseudoaneurysm.
• Adult male circumcision outcomes: experience in a developing country setting.
• Ankyloglossum superius syndrome: diagnosis and surgical management.
• Commentary: will it take harry potter to solve diabetes? Divining the future of diabetes care.
• Establishment and biochemical characterization of primary cells of the upper aerodigestive tract.
• Focusing on environmental aspect of HIV/AIDS prevalence in Abuja - Nigeria.
• Global patterns of city size distributions and their fundamental drivers.
• Identification of two novel quantitative trait loci for pre-eclampsia susceptibility on chromosomes 5q and 13q using a variance components-based linkage approach.
• Influence of the surface structure of a multiblock copolymer on the cellular behavior of primary cell cultures of the upper aerodigestive tract in vitro.
• Kaposi's sarcoma: a model of both malignancy and chronic inflammation.
• Luminal narrowing due to intramural hematoma shift from left anterior descending coronary artery to left circumflex artery.
• Magnesium disturbances in critically ill patients.
• Obstetrics in the Winchester Hospital, 1928-1947.
• Open season?
• Prevalent Herpes Simplex Virus Type 2 Infection is Associated with Altered Vaginal Flora and an increased Susceptibility to Multiple Sexually Transmitted Infections.
• Reduction of mortality in intestinal obstruction.
• Repression of vascular endothelial growth factor expression by the zinc finger transcription factor ZNF24.
• Studies on the synovial fluid and the synovial membrane of the temporomandibular joint.
• The allometry of host-pathogen interactions.
• The hSNM1 protein is a DNA 5'-exonuclease.
• The percentage of patients achieving PASI 75 after 1 month and remission time after climatotherapy at the Dead Sea.
• The prevention of arteriosclerosis.
• The specificity of immune human serum antihyaluronidase.
• The value of liver function tests in general hospital practice.
• To Cut or Not to Cut: A Modeling Approach for Assessing the Role of Male Circumcision in HIV Control.
• Vocal analysis.