A rational approach to the pharmacotherapy of alcohol dependence.

A rational approach to the pharmacotherapy of alcohol dependence. Research Abstract Details 

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A rational approach to the pharmacotherapy of alcohol dependence. Abstract Text:

Ismene L Petrakis,

The use of alcohol is widespread in the world, and although there are many regular users, some individuals drink excessively. Understanding the time course of the development and maintenance of alcohol dependence is important in assessing the potential risk/benefit of an intervention and in accurately treating the problem. Most, although not all, literature suggests that alcoholism is a chronic, relapsing disorder and that there is a general progression from less to more severe problems. Understanding the neurobiology that underlies alcohol dependence as it relates to different clinical stages may help in the development of effective targeted pharmacological treatments. Important clinical stages that may be amenable to pharmacological intervention include the transition from alcohol use to heavy drinking particularly in vulnerable individuals, the cessation of heavy drinking in individuals who want to quit, and the prevention of relapse in individuals who have initiated abstinence but may struggle with craving or the desire to resume alcohol use. Neurotransmitter systems implicated in these stages include glutamate, gamma-aminobutyric acid, opioid, and serotonin systems that may act directly or via the indirect modulation of dopamine function. The treatment implications will also be discussed.

A rational approach to the pharmacotherapy of alcohol dependence. Publishing Authors By Initials

IL Petrakis,

For similar human activities: temperance research abstracts see: human activities: temperance research

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A rational approach to the pharmacotherapy of alcohol dependence. Journal Published:

PUBLICATION TYPE: Review

Journal: Journal of clinical psychopharmacology

VOLUME: 26 Suppl 1

Page Numbers: S3-12

Journal Abbreviation:

ISSN: 0271-0749

DAY: 3

MONTH: Dec

YEAR: 2006

A rational approach to the pharmacotherapy of alcohol dependence. Information

Number of References: 133

LANGUAGE: eng

NlmUniqueID: 8109496

A rational approach to the pharmacotherapy of alcohol dependence. Keywords Mesh Terms:

KEYWORDS: Temperance

MESH TERMS: prevention & control

Chemical & Substance for Abstract: A rational approach to the pharmacotherapy of alcohol dependence. Information

Substance Name: Alcohol Deterrents

Registry Number: 0

Grant and Affiliation Information for A rational approach to the pharmacotherapy of alcohol dependence.

AFFILIATION: Department of Psychiatry and School of Medicine, Yale University, New Haven, CT 06510, USA. ismene.petrakis@yale.edu

Country: United States

AGENCY: United States NIAAA

GRANT: 1 P50 AA 12870-01

ACRONYM: AA

MEDLINETA: J Clin Psychopharmacol

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