A rapid in vitro assay for predicting thermochemosensitivity of human cancer: comparison with clonogenic assay.

A rapid in vitro assay for predicting thermochemosensitivity of human cancer: comparison with clonogenic assay. Research Abstract Details 

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A rapid in vitro assay for predicting thermochemosensitivity of human cancer: comparison with clonogenic assay. Abstract Text:

K Yamada,H A Neumann,H H Fiebig,R Engelhardt,H Tokita,

We previously reported a rapid in vitro assay based on morphological changes in the nucleus in order to predict response to thermochemotherapy. It was strongly suggested that this simple method may be clinically useful. In the present study, a comparison with the clonogenic assay was carried out on eight different human tumors (three malignant melanomas, two lung carcinomas, two colon carcinomas and one leukemia). Melphalan, mitomycin C and vincristine were tested. Correlation between the two test systems was dependent upon the criteria for each test system. At the level of less than 50% survival of colony as compared with normothermic dishes in clonogenic assay, there was a high correlation between the two test systems for sensitive tumor to 43 degrees C. In respect of response to thermochemotherapy, when only karyorrhexis changes in the nucleus were selected as an activity criteria in our cytotoxic test, parallel data between the two test systems were obtained.

A rapid in vitro assay for predicting thermochemosensitivity of human cancer: comparison with clonogenic assay. Publishing Authors By Initials

K Yamada,HA Neumann,HH Fiebig,R Engelhardt,H Tokita,

For similar investigative techniques: clinical laboratory techniques: cytological techniques: colony-forming units assay: tumor stem cell assay research abstracts see: investigative techniques: clinical laboratory techniques: cytological techniques: colony-forming units assay: tumor stem cell assay research

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A rapid in vitro assay for predicting thermochemosensitivity of human cancer: comparison with clonogenic assay. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Recent results in cancer research. Fortschritte de

VOLUME: 107

Page Numbers: 177-83

Journal Abbreviation: Recent Results Cancer Res.

ISSN: 0080-0015

DAY: 13

MONTH: 02

YEAR: 1988

A rapid in vitro assay for predicting thermochemosensitivity of human cancer: comparison with clonogenic assay. Information

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LANGUAGE: eng

NlmUniqueID: 44671

A rapid in vitro assay for predicting thermochemosensitivity of human cancer: comparison with clonogenic assay. Keywords Mesh Terms:

KEYWORDS: Tumor Stem Cell Assay

MESH TERMS: drug effects

Chemical & Substance for Abstract: A rapid in vitro assay for predicting thermochemosensitivity of human cancer: comparison with clonogenic assay. Information

Substance Name: Antineoplastic Agents

Registry Number: 0

Grant and Affiliation Information for A rapid in vitro assay for predicting thermochemosensitivity of human cancer: comparison with clonogenic assay.

AFFILIATION: Medizinische Klinik, Albert-Ludwigs-Universität, Freiburg, FRG.

Country: GERMANY, WEST

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MEDLINETA: Recent Results Cancer Res

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