A rapid and sensitive method for the quantitation of montelukast in sheep plasma using liquid chromatography/tandem mass spectrometry.

A rapid and sensitive method for the quantitation of montelukast in sheep plasma using liquid chromatography/tandem mass spectrometry. Research Abstract Details 

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A rapid and sensitive method for the quantitation of montelukast in sheep plasma using liquid chromatography/tandem mass spectrometry. Abstract Text:

Robert Papp,Pauline Luk,Wayne M Mullett,Elizabeth Kwong,Robert Papp,Pauline Luk,Wayne M Mullett,Elizabeth Kwong,Robert Papp,Pauline Luk,Wayne M Mullett,Elizabeth Kwong,

A rapid LC-MS/MS method was developed and partially validated for the quantitation of montelukast in spiked sheep plasma. A total run time of 1.5 min was achieved using a short monolithic column and employing a rapid gradient. Sample preparation involved protein precipitation with twofold acetonitrile by volume during which a deuterated internal standard (montelukast D-6) was incorporated. The MRM transitions for montelukast and the deuterated internal standard were 586/422 and 592/427, respectively. A linear dynamic range of 0.25-500 ng/mL with a correlation coefficient of 0.9999 was achieved. Precision was below 5% at all levels except at the LOQ (0.36 ng/mL) which demonstrated an overall of R.S.D. of 8%. Post-column infusion experiments were performed with precipitated plasma matrix and showed minimal interference with the peaks of interest.

A rapid and sensitive method for the quantitation of montelukast in sheep plasma using liquid chromatography/tandem mass spectrometry. Publishing Authors By Initials

R Papp,P Luk,WM Mullett,E Kwong,R Papp,P Luk,WM Mullett,E Kwong,R Papp,P Luk,WM Mullett,E Kwong,

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A rapid and sensitive method for the quantitation of montelukast in sheep plasma using liquid chromatography/tandem mass spectrometry. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of chromatography. B, Analytical technolog

VOLUME: 858

Page Numbers: 282-6

Journal Abbreviation: J. Chromatogr. B Analyt. Techn

ISSN: 1570-0232

DAY: 7

MONTH: 08

YEAR: 2007

A rapid and sensitive method for the quantitation of montelukast in sheep plasma using liquid chromatography/tandem mass spectrometry. Information

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LANGUAGE: eng

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Grant and Affiliation Information for A rapid and sensitive method for the quantitation of montelukast in sheep plasma using liquid chromatography/tandem mass spectrometry.

AFFILIATION: Pharmaceutical Research and Development, Merck Frosst Center for Therapeutic Research, 16711 Trans Canada Hwy., Kirkland, Quebec, Canada H9H 3L1. robert_papp@merck.com

Country: Netherlands

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MEDLINETA: J Chromatogr B Analyt Technol

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