A rapid and inexpensive method to screen for common foods that reduce the action of acrylamide, a harmful substance in food.

A rapid and inexpensive method to screen for common foods that reduce the action of acrylamide, a harmful substance in food. Research Abstract Details 

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A rapid and inexpensive method to screen for common foods that reduce the action of acrylamide, a harmful substance in food. Abstract Text:

Koichi Hasegawa,Satsuki Miwa,Tomoko Tajima,Kaname Tsutsumiuchi,Hajime Taniguchi,Johji Miwa,Koichi Hasegawa,Satsuki Miwa,Tomoko Tajima,Kaname Tsutsumiuchi,Hajime Taniguchi,Johji Miwa,Koichi Hasegawa,Satsuki Miwa,Tomoko Tajima,Kaname Tsutsumiuchi,Hajime Taniguchi,Johji Miwa,

By DNA microarray and protein 2-DE screens for Caenorhabditis elegans genes up-regulated by acrylamide, we selected the gst-4 gene and constructed a gst::gfp fusion gene, which was used to transform C. elegans into a biosensor for acrylamide. This biosensor detects acrylamide as a GFP-expression signal in a dose- and time-dependent manner. When the biosensor was exposed to acrylamide together with commercially available powdered green tea, GFP levels decreased to the control level, suggestive of acrylamide detoxification or prevention of GST induction. The present methodology should be applicable for screening of not only harmful substances but also substances that reduce or counteract their harmfulness or action, with appropriately constructed visible biosensors.

A rapid and inexpensive method to screen for common foods that reduce the action of acrylamide, a harmful substance in food. Publishing Authors By Initials

K Hasegawa,S Miwa,T Tajima,K Tsutsumiuchi,H Taniguchi,J Miwa,K Hasegawa,S Miwa,T Tajima,K Tsutsumiuchi,H Taniguchi,J Miwa,K Hasegawa,S Miwa,T Tajima,K Tsutsumiuchi,H Taniguchi,J Miwa,

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A rapid and inexpensive method to screen for common foods that reduce the action of acrylamide, a harmful substance in food. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Toxicology letters

VOLUME: 175

Page Numbers: 82-8

Journal Abbreviation: Toxicol. Lett.

ISSN: 0378-4274

DAY: 7

MONTH: 10

YEAR: 2007

A rapid and inexpensive method to screen for common foods that reduce the action of acrylamide, a harmful substance in food. Information

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LANGUAGE: eng

NlmUniqueID: 7709027

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Grant and Affiliation Information for A rapid and inexpensive method to screen for common foods that reduce the action of acrylamide, a harmful substance in food.

AFFILIATION: Institute for Biological Function, Chubu University, 1200 Matsumoto, Kasugai 487-8501, Japan; Graduate School of Agriculture, Kyoto University, Sakyo-ku, Kyoto 606-8502, Japan.

Country: Netherlands

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MEDLINETA: Toxicol Lett

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