A randomized controlled study of effects of dietary magnesium oxide supplementation on bone mineral content in healthy girls.

A randomized controlled study of effects of dietary magnesium oxide supplementation on bone mineral content in healthy girls. Research Abstract Details 

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A randomized controlled study of effects of dietary magnesium oxide supplementation on bone mineral content in healthy girls. Abstract Text:

Thomas O Carpenter,Maria C DeLucia,Jane Hongyuan Zhang,Gina Bejnerowicz,Lisa Tartamella,James Dziura,Kitt Falk Petersen,Douglas Befroy,Dorothy Cohen,

CONTEXT: The role of magnesium (Mg) as a determinant of bone mass has not been extensively explored. Limited studies suggest that dietary Mg intake and bone mineral density are correlated in adults, but no data from interventional studies in children and adolescents are available. OBJECTIVE: We sought to determine whether Mg supplementation in periadolescent girls enhances accrual of bone mass. DESIGN: We carried out a prospective, placebo-controlled, randomized, one-year double-blind trial of Mg supplementation. SETTING: The study was conducted in the Clinical Research Centers at Yale University School of Medicine. PATIENTS OR OTHER PARTICIPANTS: Healthy 8- to 14-yr-old Caucasian girls were recruited from community pediatricians' offices. Dietary diaries from over 120 volunteers were analyzed, and those with dietary Mg intake of less than 220 mg/d were invited to participate in the intervention. INTERVENTION: Magnesium (300 mg elemental Mg per day in two divided doses) or placebo was given orally for 12 months. MAIN OUTCOME MEASURE: The primary outcome measure was interval change in bone mineral content (BMC) of the total hip, femoral neck, Ward's area, and lumbar spine (L1-L4) after 12 months of Mg supplementation. RESULTS: Significantly increased accrual (P = 0.05) in integrated hip BMC occurred in the Mg-supplemented vs. placebo group. Trends for a positive Mg effect were evident in the pre- and early puberty and in mid-late puberty. Lumbar spinal BMC accrual was slightly (but not significantly) greater in the Mg-treated group. Compliance was excellent; 73% of capsules were ingested as inferred by pill counts. Serum mineral levels, calciotropic hormones, and bone markers were similar between groups. CONCLUSIONS: Oral Mg oxide capsules are safe and well tolerated. A positive effect of Mg supplementation on integrated hip BMC was evident in this small cohort.

A randomized controlled study of effects of dietary magnesium oxide supplementation on bone mineral content in healthy girls. Publishing Authors By Initials

TO Carpenter,MC DeLucia,JH Zhang,G Bejnerowicz,L Tartamella,J Dziura,KF Petersen,D Befroy,D Cohen,

For similar pharmaceutical preparations: placebos research abstracts see: pharmaceutical preparations: placebos research

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A randomized controlled study of effects of dietary magnesium oxide supplementation on bone mineral content in healthy girls. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Journal of clinical endocrinology and metaboli

VOLUME: 91

Page Numbers: 4866-72

Journal Abbreviation: J. Clin. Endocrinol. Metab.

ISSN: 0021-972X

DAY: 3

MONTH: 10

YEAR: 2006

A randomized controlled study of effects of dietary magnesium oxide supplementation on bone mineral content in healthy girls. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 375362

A randomized controlled study of effects of dietary magnesium oxide supplementation on bone mineral content in healthy girls. Keywords Mesh Terms:

KEYWORDS: Placebos

MESH TERMS: pharmacology

Chemical & Substance for Abstract: A randomized controlled study of effects of dietary magnesium oxide supplementation on bone mineral content in healthy girls. Information

Substance Name: Magnesium Oxide

Registry Number: 1309-48-4

Grant and Affiliation Information for A randomized controlled study of effects of dietary magnesium oxide supplementation on bone mineral content in healthy girls.

AFFILIATION: Department of Pediatrics, Yale University School of Medicine, New Haven, Connecticut 06520-8064, USA. thomas.carpenter@yale.edu

Country: United States

AGENCY: United States PHS

GRANT: R01-AGG23686

ACRONYM: DK

MEDLINETA: J Clin Endocrinol Metab

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