A randomised controlled trial of prophylactic levonorgestrel intrauterine system in tamoxifen-treated women.

A randomised controlled trial of prophylactic levonorgestrel intrauterine system in tamoxifen-treated women. Research Abstract Details 

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A randomised controlled trial of prophylactic levonorgestrel intrauterine system in tamoxifen-treated women. Abstract Text:

S S C Chan,W H Tam,W Yeo,M M Y Yu,D P S Ng,A W Y Wong,W H Kwan,P M Yuen,S S C Chan,W H Tam,W Yeo,M M Y Yu,D P S Ng,A W Y Wong,W H Kwan,P M Yuen,

OBJECTIVE: To study the prophylactic use of levonorgestrel intrauterine system (LNG-IUS) in the prevention of endometrial pathology in women having breast cancer treated with tamoxifen. DESIGN: Randomised controlled trial. SETTING: A tertiary teaching hospital. POPULATION: One hundred and thirteen women (66 premenopausal/47 postmenopausal) who required adjuvant tamoxifen for breast cancer after the completion of postoperative radiotherapy and chemotherapy. METHODS: Women were randomised to treatment group (prophylactic LNG-IUS insertion before the commencement of tamoxifen) or control group. Uterine cavity was examined by outpatient hysteroscopy and endometrial biopsy before and at 12 months after commencement of tamoxifen. MAIN OUTCOME MEASURES: De novo endometrial pathology at 1 year of tamoxifen. RESULTS: Women in the treatment group had a much lower incidence of endometrial polyp (1.8 versus 15.5%, P= 0.017) (relative risk: 0.12; 95% CI: 0.02-0.91) at 12 months. There was no significant difference in the incidence of submucosal fibroid between the two groups (1.8 versus 3.4%, P= 1.0). LNG-IUS was retained in 95% women in the treatment group at 1 year. CONCLUSION: LNG-IUS reduces the occurrence of de novo endometrial polyp in women treated with tamoxifen for breast cancer.

A randomised controlled trial of prophylactic levonorgestrel intrauterine system in tamoxifen-treated women. Publishing Authors By Initials

SS Chan,WH Tam,W Yeo,MM Yu,DP Ng,AW Wong,WH Kwan,PM Yuen,SS Chan,WH Tam,W Yeo,MM Yu,DP Ng,AW Wong,WH Kwan,PM Yuen,

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A randomised controlled trial of prophylactic levonorgestrel intrauterine system in tamoxifen-treated women. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: BJOG : an international journal of obstetrics and

VOLUME: 114

Page Numbers: 1510-5

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ISSN: 1471-0528

DAY: 12

MONTH: Dec

YEAR: 2007

A randomised controlled trial of prophylactic levonorgestrel intrauterine system in tamoxifen-treated women. Information

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LANGUAGE: eng

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AFFILIATION: Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories, Hong Kong. symphorosa@cuhk.edu.hk

Country: England

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MEDLINETA: BJOG

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