A "class action" against the microenvironment: do cancer cells cooperate in metastasis?

A "class action" against the microenvironment: do cancer cells cooperate in metastasis? Research Abstract Details 

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A "class action" against the microenvironment: do cancer cells cooperate in metastasis? Abstract Text:

The authors review how cancer cells may cooperate in metastasis by means of microenvironmental changes. The main mechanisms underlying this cooperation are clustered migration of cancer cells, extracellular matrix degradation, paracrine loops of released signaling factors and/or induction of adhesion molecules on stromal cells. Another critical factor could be temporal cooperation: successive waves of cancer cells may induce progressive conditioning of the microenvironment. The "class action" of cancer cells against the microenvironment involves successive steps of the metastatic process: invasion of the primary tumor microenvironment, collective migration through the extracellular matrix, blood vessel disruption, vascular or lymphatic tumor emboli, establishment of a premetastatic niche by secreted factors and endothelial precursor recruitment, induction of cell adhesion molecule expression in endothelial cells, extravasation, micrometastasis dormancy and establishment of a new growth in distant sites. As a result, after completion of the metastatic process, the series of microenvironmental changes from the primary tumor to the metastatic site may promote colonization of metastases by nonmetastatic cancer cells of the primary tumor.

A "class action" against the microenvironment: do cancer cells cooperate in metastasis? Publishing Authors By Initials

For similar neoplasms research abstracts see: neoplasms research

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A "class action" against the microenvironment: do cancer cells cooperate in metastasis? Journal Published:

PUBLICATION TYPE: Review

Journal: Cancer metastasis reviews

VOLUME: 27

Page Numbers: 5-10

Journal Abbreviation: Cancer Metastasis Rev.

ISSN: 0167-7659

DAY: 11

MONTH: Mar

YEAR: 2008

A "class action" against the microenvironment: do cancer cells cooperate in metastasis? Information

Number of References: 60

LANGUAGE: eng

NlmUniqueID: 8605731

A "class action" against the microenvironment: do cancer cells cooperate in metastasis? Keywords Mesh Terms:

KEYWORDS: Neoplasms

MESH TERMS: pathology

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Grant and Affiliation Information for A "class action" against the microenvironment: do cancer cells cooperate in metastasis?

AFFILIATION: Department of Translational Research, Institut Curie, 26 rue d'Ulm, 75005, Paris, France.

Country: Netherlands

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MEDLINETA: Cancer Metastasis Rev

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