A Quinone Isolated from the Nest of Vespa simillima and Its Growth-Inhibitory Effect on Rat Liver Cancer Cells.

A Quinone Isolated from the Nest of Vespa simillima and Its Growth-Inhibitory Effect on Rat Liver Cancer Cells. Research Abstract Details 

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A Quinone Isolated from the Nest of Vespa simillima and Its Growth-Inhibitory Effect on Rat Liver Cancer Cells. Abstract Text:

Yumiko Fujiwara,Makoto Mangetsu,Ping Yang,Hisayoshi Kofujita,Koichi Suzuki,Yasufumi Ohfune,Tetsuro Shinada,

A biologically active quinone that exhibits a growth-inhibitory effect on rat liver cancer cells was isolated from the nest of a social wasp, Vespa simillima (Vespinae, Vespidae). The structure was unambiguously determined by NMR and synthetic experiments and identified as being 7,8-seco-para-ferruginone. The synthetic quinone showed potent growth-inhibitory effects on rat hepatoma cells (IC(50) value=1.9 muM). Morphological analyses of dRLh84 cells using the synthetic compound were tested. Chromatin coagulation was induced by the synthetic compound at 31.6 muM.

A Quinone Isolated from the Nest of Vespa simillima and Its Growth-Inhibitory Effect on Rat Liver Cancer Cells. Publishing Authors By Initials

Y Fujiwara,M Mangetsu,P Yang,H Kofujita,K Suzuki,Y Ohfune,T Shinada,

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A Quinone Isolated from the Nest of Vespa simillima and Its Growth-Inhibitory Effect on Rat Liver Cancer Cells. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Biological & pharmaceutical bulletin

VOLUME: 31

Page Numbers: 722-5

Journal Abbreviation: Biol. Pharm. Bull.

ISSN: 0918-6158

DAY: 1

MONTH: Apr

YEAR: 2008

A Quinone Isolated from the Nest of Vespa simillima and Its Growth-Inhibitory Effect on Rat Liver Cancer Cells. Information

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LANGUAGE: eng

NlmUniqueID: 9311984

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Grant and Affiliation Information for A Quinone Isolated from the Nest of Vespa simillima and Its Growth-Inhibitory Effect on Rat Liver Cancer Cells.

AFFILIATION: Graduate School of Agriculture, Iwate University.

Country: Japan

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MEDLINETA: Biol Pharm Bull

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