A quantum dot conjugated sugar ball and its cellular uptake. On the size effects of endocytosis in the subviral region.

A quantum dot conjugated sugar ball and its cellular uptake. On the size effects of endocytosis in the subviral region. Research Abstract Details 

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A quantum dot conjugated sugar ball and its cellular uptake. On the size effects of endocytosis in the subviral region. Abstract Text:

Fumio Osaki,Takuya Kanamori,Shinsuke Sando,Takashi Sera,Yasuhiro Aoyama,

The lipophilic CdSe quantum dot (QD) coated with trioctylphosphine oxide (TOPOQD) can be extracted from chloroform into water upon interaction with macrocyclic glycocluster amphiphile 1. The QD-conjugated and highly fluorescent sugar ball of a size of 15 nm (TOPOQD1) thus solubilized in water readily invades Hela cells via endocytosis. The endocytic activity of TOPOQD1 (15 nm), in light of those of the micellar homoaggregate of 1 (5 nm) and the virus-like 1-DNA conjugate (50 nm) as references, reveals a dramatic size effect (50 > 15 > 5) in the subviral size region. The optimal size at approximately 50 nm indicates that size complementarity which governs molecular recognition in small host-guest systems also plays key roles in the encapsulation of nanometric guest particles by the endocytic vesicles (

A quantum dot conjugated sugar ball and its cellular uptake. On the size effects of endocytosis in the subviral region. Publishing Authors By Initials

F Osaki,T Kanamori,S Sando,T Sera,Y Aoyama,

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A quantum dot conjugated sugar ball and its cellular uptake. On the size effects of endocytosis in the subviral region. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of the American Chemical Society

VOLUME: 126

Page Numbers: 6520-1

Journal Abbreviation: J. Am. Chem. Soc.

ISSN: 0002-7863

DAY: 2

MONTH: Jun

YEAR: 2004

A quantum dot conjugated sugar ball and its cellular uptake. On the size effects of endocytosis in the subviral region. Information

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LANGUAGE: eng

NlmUniqueID: 7503056

A quantum dot conjugated sugar ball and its cellular uptake. On the size effects of endocytosis in the subviral region. Keywords Mesh Terms:

KEYWORDS: Viruses

MESH TERMS: chemistry

Chemical & Substance for Abstract: A quantum dot conjugated sugar ball and its cellular uptake. On the size effects of endocytosis in the subviral region. Information

Substance Name: Oligosaccharides

Registry Number: 0

Grant and Affiliation Information for A quantum dot conjugated sugar ball and its cellular uptake. On the size effects of endocytosis in the subviral region.

AFFILIATION: Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Nishikyo-ku, Kyoto 615-8510, Japan.

Country: United States

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MEDLINETA: J Am Chem Soc

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