A quantitative, theoretical framework for understanding mammalian sleep.

A quantitative, theoretical framework for understanding mammalian sleep. Research Abstract Details 

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A quantitative, theoretical framework for understanding mammalian sleep. Abstract Text:

Van M Savage,Geoffrey B West,

Sleep is one of the most noticeable and widespread phenomena occurring in multicellular animals. Nevertheless, no consensus for a theory of its origins has emerged. In particular, no explicit, quantitative theory exists that elucidates or distinguishes between the myriad hypotheses proposed for sleep. Here, we develop a general, quantitative theory for mammalian sleep that relates many of its fundamental parameters to metabolic rate and body size. Several mechanisms suggested for the function of sleep can be placed in this framework, e.g., cellular repair of damage caused by metabolic processes as well as cortical reorganization to process sensory input. Our theory leads to predictions for sleep time, sleep cycle time, and rapid eye movement time as functions of body and brain mass, and it explains, for example, why mice sleep approximately 14 hours per day relative to the 3.5 hours per day that elephants sleep. Data for 96 species of mammals, spanning six orders of magnitude in body size, are consistent with these predictions and provide strong evidence that time scales for sleep are set by the brain's, not the whole-body, metabolic rate.

A quantitative, theoretical framework for understanding mammalian sleep. Publishing Authors By Initials

VM Savage,GB West,

For similar natural sciences: time: time factors research abstracts see: natural sciences: time: time factors research

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A quantitative, theoretical framework for understanding mammalian sleep. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Proceedings of the National Academy of Sciences of

VOLUME: 104

Page Numbers: 1051-6

Journal Abbreviation: Proc. Natl. Acad. Sci. U.S.A.

ISSN: 0027-8424

DAY: 10

MONTH: 01

YEAR: 2007

A quantitative, theoretical framework for understanding mammalian sleep. Information

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LANGUAGE: eng

NlmUniqueID: 7505876

A quantitative, theoretical framework for understanding mammalian sleep. Keywords Mesh Terms:

KEYWORDS: Time Factors

MESH TERMS: physiology

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Grant and Affiliation Information for A quantitative, theoretical framework for understanding mammalian sleep.

AFFILIATION: Santa Fe Institute, 1399 Hyde Park Road, Santa Fe, NM 87501, USA. van_savage@hms.harvard.edu

Country: United States

AGENCY: United States NIGMS

GRANT: 1P50 GM 68763-02

ACRONYM: GM

MEDLINETA: Proc Natl Acad Sci U S A

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