A quantitative overview of glucose dynamics in the gliovascular unit.

A quantitative overview of glucose dynamics in the gliovascular unit. Research Abstract Details 

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A quantitative overview of glucose dynamics in the gliovascular unit. Abstract Text:

L F Barros,Carla X Bittner,Anitsi Loaiza,Omar H Porras,

While glucose is constantly being "pulled" into the brain by hexokinase, its flux across the blood brain barrier (BBB) is allowed by facilitative carriers of the GLUT family. Starting from the microscopic properties of GLUT carriers, and within the constraints imposed by the available experimental data, chiefly NMR spectroscopy, we have generated a numerical model that reveals several hidden features of glucose transport and metabolism in the brain. The half-saturation constant of glucose uptake into the brain (K(t)) is close to 8 mM. GLUT carriers at the BBB are symmetric, show accelerated-exchange, and a K(m) of zero-trans flux (K(zt)) close to 5 mM, determining a ratio of 3.6 between maximum transport rate and net glucose flux (T(max)/CMR(glc)). In spite of the low transporter occupancy, the model shows that for a stimulated hexokinase to pull more glucose into the brain, the number or activity of GLUT carriers must also increase, particularly at the BBB. The endothelium is therefore predicted to be a key modulated element for the fast control of energy metabolism. In addition, the simulations help to explain why mild hypoglycemia may be asymptomatic and reveal that [glucose](brain) (as measured by NMR) should be much more sensitive than glucose flux (as measured by PET) as an indicator of GLUT1 deficiency. In summary, available data from various sources has been integrated in a predictive model based on the microscopic properties of GLUT carriers.

A quantitative overview of glucose dynamics in the gliovascular unit. Publishing Authors By Initials

LF Barros,CX Bittner,A Loaiza,OH Porras,

For similar nervous system: neuroglia research abstracts see: nervous system: neuroglia research

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A quantitative overview of glucose dynamics in the gliovascular unit. Journal Published:

PUBLICATION TYPE: Review

Journal: Glia

VOLUME: 55

Page Numbers: 1222-37

Journal Abbreviation: Glia

ISSN: 0894-1491

DAY: 3

MONTH: Sep

YEAR: 2007

A quantitative overview of glucose dynamics in the gliovascular unit. Information

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LANGUAGE: eng

NlmUniqueID: 8806785

A quantitative overview of glucose dynamics in the gliovascular unit. Keywords Mesh Terms:

KEYWORDS: Neuroglia

MESH TERMS: metabolism

Chemical & Substance for Abstract: A quantitative overview of glucose dynamics in the gliovascular unit. Information

Substance Name: Glucose

Registry Number: 50-99-7

Grant and Affiliation Information for A quantitative overview of glucose dynamics in the gliovascular unit.

AFFILIATION: Centro de Estudios Científicos (CECS), Av. Arturo Prat 514, Casilla 1469, Valdivia, Chile. fbarros@cecs.cl

Country: United States

AGENCY: United States FIC

GRANT: R03 TW007024-01A1

ACRONYM: TW

MEDLINETA: Glia

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