A putative quantitative trait locus on chromosome 20 associated with bovine pathogenic disease incidence.

A putative quantitative trait locus on chromosome 20 associated with bovine pathogenic disease incidence. Research Abstract Details 

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A putative quantitative trait locus on chromosome 20 associated with bovine pathogenic disease incidence. Abstract Text:

The objective of this study was to detect QTL associated with the incidence of multiple pathogenic diseases in offspring from half-sib bovine families. Four F(1) sires were used to produce offspring: Brahman x Hereford (BH; n = 547), Piedmontese x Angus (PA; n = 209), Brahman x Angus (n = 176), and Belgian Blue x MARC III (n = 246). Treatment records for bovine respiratory disease, infectious keratoconjunctivitis (pinkeye), and infectious pododermatitis (footrot) were available for all of the offspring from birth to slaughter. The incidences of these 3 microbial pathogenic diseases were combined into a single binary trait to represent an overall pathogenic disease incidence. Offspring diagnosed and treated for 1 or more of the previously mentioned pathogenic diseases were coded as a 1 for affected. Cattle with no treatment record were coded as 0 for healthy. A putative QTL for pathogenic disease incidence was detected in the family derived from the BH sire at the genome-wise suggestive level. This was supported by evidence, in the same chromosomal region, of a similar QTL in the family derived from the PA sire. The maximum F-statistic (F = 13.52; P = 0.0003) was located at cM 18. The support interval of the QTL spanned from cM 9 to 28. Further studies should explore this QTL by using other bovine populations to further confirm the QTL and refine the QTL support interval. Offspring inheriting the Hereford allele, in the family from the BH sire, and the Angus allele, in the family from the PA sire, were less susceptible to incidence of pathogenic diseases, when compared with those inheriting the Brahman allele and Piedmontese allele, from the BH and PA sires, respectively.

A putative quantitative trait locus on chromosome 20 associated with bovine pathogenic disease incidence. Publishing Authors By Initials

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A putative quantitative trait locus on chromosome 20 associated with bovine pathogenic disease incidence. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of animal science

VOLUME: 86

Page Numbers: 2455-60

Journal Abbreviation: J. Anim. Sci.

ISSN: 1525-3163

DAY: 23

MONTH: 05

YEAR: 2008

A putative quantitative trait locus on chromosome 20 associated with bovine pathogenic disease incidence. Information

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LANGUAGE: eng

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Grant and Affiliation Information for A putative quantitative trait locus on chromosome 20 associated with bovine pathogenic disease incidence.

AFFILIATION: US Meat Animal Research Center, USDA, ARS, Clay Center, NE 68933, USA. eduardo.casas@ars.usda.gov

Country: United States

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MEDLINETA: J Anim Sci

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