A Putative Cation Channel, NCA-1, and a Novel Protein, UNC-80, Transmit Neuronal Activity in C. elegans.

A Putative Cation Channel, NCA-1, and a Novel Protein, UNC-80, Transmit Neuronal Activity in C. elegans. Research Abstract Details 

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A Putative Cation Channel, NCA-1, and a Novel Protein, UNC-80, Transmit Neuronal Activity in C. elegans. Abstract Text:

Edward Yeh,Sharon Ng,Mi Zhang,Magali Bouhours,Ying Wang,Min Wang,Wesley Hung,Kyota Aoyagi,Katya Melnik-Martinez,Michelle Li,Fang Liu,William R Schafer,Mei Zhen,Edward Yeh,Sharon Ng,Mi Zhang,Magali Bouhours,Ying Wang,Min Wang,Wesley Hung,Kyota Aoyagi,Katya Melnik-Martinez,Michelle Li,Fang Liu,William R Schafer,Mei Zhen,

Voltage-gated cation channels regulate neuronal excitability through selective ion flux. NALCN, a member of a protein family that is structurally related to the alpha1 subunits of voltage-gated sodium/calcium channels, was recently shown to regulate the resting membrane potentials by mediating sodium leak and the firing of mouse neurons. We identified a role for the Caenorhabditis elegans NALCN homologues NCA-1 and NCA-2 in the propagation of neuronal activity from cell bodies to synapses. Loss of NCA activities leads to reduced synaptic transmission at neuromuscular junctions and frequent halting in locomotion. In vivo calcium imaging experiments further indicate that while calcium influx in the cell bodies of egg-laying motorneurons is unaffected by altered NCA activity, synaptic calcium transients are significantly reduced in nca loss-of-function mutants and increased in nca gain-of-function mutants. NCA-1 localizes along axons and is enriched at nonsynaptic regions. Its localization and function depend on UNC-79, and UNC-80, a novel conserved protein that is also enriched at nonsynaptic regions. We propose that NCA-1 and UNC-80 regulate neuronal activity at least in part by transmitting depolarization signals to synapses in C. elegans neurons.

A Putative Cation Channel, NCA-1, and a Novel Protein, UNC-80, Transmit Neuronal Activity in C. elegans. Publishing Authors By Initials

E Yeh,S Ng,M Zhang,M Bouhours,Y Wang,M Wang,W Hung,K Aoyagi,K Melnik-Martinez,M Li,F Liu,WR Schafer,M Zhen,E Yeh,S Ng,M Zhang,M Bouhours,Y Wang,M Wang,W Hung,K Aoyagi,K Melnik-Martinez,M Li,F Liu,WR Schafer,M Zhen,

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A Putative Cation Channel, NCA-1, and a Novel Protein, UNC-80, Transmit Neuronal Activity in C. elegans. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: PLoS biology

VOLUME: 6

Page Numbers: e55

Journal Abbreviation: PLoS Biol.

ISSN: 1545-7885

DAY: 11

MONTH: Mar

YEAR: 2008

A Putative Cation Channel, NCA-1, and a Novel Protein, UNC-80, Transmit Neuronal Activity in C. elegans. Information

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LANGUAGE: eng

NlmUniqueID: 101183755

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