A putative cation channel and its novel regulator: cross-species conservation of effects on general anesthesia.

A putative cation channel and its novel regulator: cross-species conservation of effects on general anesthesia. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

A putative cation channel and its novel regulator: cross-species conservation of effects on general anesthesia. Abstract Text:

John A Humphrey,Kevin S Hamming,Colin M Thacker,Robert L Scott,Margaret M Sedensky,Terrance P Snutch,Phil G Morgan,Howard A Nash,

Volatile anesthetics like halothane and enflurane are of interest to clinicians and neuroscientists because of their ability to preferentially disrupt higher functions that make up the conscious state. All volatiles were once thought to act identically; if so, they should be affected equally by genetic variants. However, mutations in two distinct genes, one in Caenorhabditis and one in Drosophila, have been reported to produce much larger effects on the response to halothane than enflurane [1, 2]. To see whether this anesthesia signature is adventitious or fundamental, we have identified orthologs of each gene and determined the mutant phenotype within each species. The fly gene, narrow abdomen (na), encodes a putative ion channel whose sequence places it in a unique family; the nematode gene, unc-79, is identified here as encoding a large cytosolic protein that lacks obvious motifs. In Caenorhabditis, mutations that inactivate both of the na orthologs produce an Unc-79 phenotype; in Drosophila, mutations that inactivate the unc-79 ortholog produce an na phenotype. In each organism, studies of double mutants place the genes in the same pathway, and biochemical studies show that proteins of the UNC-79 family control NA protein levels by a posttranscriptional mechanism. Thus, the anesthetic signature reflects an evolutionarily conserved role for the na orthologs, implying its intimate involvement in drug action.

A putative cation channel and its novel regulator: cross-species conservation of effects on general anesthesia. Publishing Authors By Initials

JA Humphrey,KS Hamming,CM Thacker,RL Scott,MM Sedensky,TP Snutch,PG Morgan,HA Nash,

For similar genetic phenomena: phenotype research abstracts see: genetic phenomena: phenotype research

PUBMED ID PMID:

MEDLINE DATE:

A putative cation channel and its novel regulator: cross-species conservation of effects on general anesthesia. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Current biology : CB

VOLUME: 17

Page Numbers: 624-9

Journal Abbreviation: Curr. Biol.

ISSN: 0960-9822

DAY: 15

MONTH: 03

YEAR: 2007

A putative cation channel and its novel regulator: cross-species conservation of effects on general anesthesia. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9107782

A putative cation channel and its novel regulator: cross-species conservation of effects on general anesthesia. Keywords Mesh Terms:

KEYWORDS: Phenotype

MESH TERMS: metabolism

Chemical & Substance for Abstract: A putative cation channel and its novel regulator: cross-species conservation of effects on general anesthesia. Information

Substance Name: Halothane

Registry Number: 151-67-7

Grant and Affiliation Information for A putative cation channel and its novel regulator: cross-species conservation of effects on general anesthesia.

AFFILIATION: Department of Genetics, Case Medical Center, Cleveland, OH 44106, USA.

Country: England

AGENCY: United States NIGMS

GRANT: T32 GM008613

ACRONYM: GM

MEDLINETA: Curr Biol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

A putative cation channel and its novel regulator: cross-species conservation of effects on general anesthesia Related Publications

• A putative cation channel and its novel regulator: cross-species conservation of effects on general anesthesia.
• Analysis of leukocyte migration through monolayers of cultured endothelial cells.
• Application of ICP-MS as a Multi-Element Detector for Sulfur and Metal Hydride Impurities in Hydrocarbon Matrices.
• Application of XML Database Technology to Biological Pathway Datasets.
• Closure of temporary stoma after anterior resection.
• Comparative genomic analysis of Campylobacter jejuni associated with Guillain-Barré and Miller Fisher syndromes: neuropathogenic and enteritis-associated isolates can share high levels of genomic similarity.
• Dietary supplementation with fish oil modifies the ability of human monocytes to induce an inflammatory response.
• Drosophila TRP channels require a protein with a distinctive motif encoded by the inaF locus.
• Finite Element Modelling of Breast Biomechanics: Finding a Reference aState.
• Finite element modelling of breast biomechanics: directly calculating the reference state.
• Frictional contact mechanics methods for soft materials: Application to tracking breast cancers.
• GTN headaches and reduction of natural banding?
• How and why do we measure surgical risk?
• Ideological and personal zeal reactions to threat among people with high self-esteem: motivated promotion focus.
• Leprosaria--a continuing social challenge.
• Modulation of endothelial responses by the stromal microenvironment: effects on leucocyte recruitment.
• Ontology-based aggregation of biological pathway datasets.
• Open repair does not equate to Lichtenstein.
• Radiographic evidence of intermittent protrusion of an intervertebral disc; case report.
• Should indeterminate lung lesions reported on staging CT scans influence the management of patients with colorectal cancer?
• Stability of benzoyl peroxide in aromatic ester-containing topical formulations.
• Studying bacterial genome dynamics using microarray-based comparative genomic hybridization.
• The Relationship Between Television Advertising, Children's Viewing and Their Requests to Father Christmas.
• The Tennessee four quarter plan after 18 years.
• The climacteric syndrome.
• The effect of beta-halogenated ethylamine derivatives on ventricular fibrillation and on the isolated heart.
• The future of disease management. Interview by Ian Morrison.
• Tissue factor (TF) and vascular endothelial growth factor (VEGF) expression in colorectal cancer: relation with cancer recurrence.
• Towards tracking breast cancer across medical images using subject-specific biomechanical models.
• Weight changes and sex incidence of tuberculosis.