A pulsed triple ionization source for sequential ion/ion reactions in an electrodynamic ion trap.

A pulsed triple ionization source for sequential ion/ion reactions in an electrodynamic ion trap. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

A pulsed triple ionization source for sequential ion/ion reactions in an electrodynamic ion trap. Abstract Text:

Xiaorong Liang,Hongling Han,Yu Xia,Scott A McLuckey,

A pulsed triple ionization source, using a common atmosphere/vacuum interface and ion path, has been developed to generate different types of ions for sequential ion/ion reaction experiments in a linear ion trap-based tandem mass spectrometer. The triple ionization source typically consists of a nano-electrospray emitter for analyte formation and two other emitters, an electrospray emitter and an atmospheric pressure chemical ionization emitter or a second nano-electrospray emitter for formation of the two different reagent ions. The three emitters are positioned in a parallel fashion close to the sampling orifice of the tandem mass spectrometer. The potentials applied to each emitter are sequentially pulsed so that desired ions are generated separately in time and space. Sequential ion/ion reactions take place after analyte ions of interest and different set of reagent ions are sequentially injected into a linear ion trap, where axial trapping is effected by applying an auxiliary radio frequency voltage to the end lenses. The pulsed triple ionization source allows independent optimization of each emitter and can be readily coupled to any atmospheric pressure ionization interface with no need for instrument modifications, provided the potentials required to transmit the ion polarity of interest can be synchronized with the emitter potentials. Several sequential ion/ion reactions examples are demonstrated to illustrate the analytical usefulness of the triple ionization source in the study of gas-phase ion/ion chemistry.

A pulsed triple ionization source for sequential ion/ion reactions in an electrodynamic ion trap. Publishing Authors By Initials

X Liang,H Han,Y Xia,SA McLuckey,

For similar proteins: ubiquitins: ubiquitin research abstracts see: proteins: ubiquitins: ubiquitin research

PUBMED ID PMID:

MEDLINE DATE:

A pulsed triple ionization source for sequential ion/ion reactions in an electrodynamic ion trap. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of the American Society for Mass Spectrome

VOLUME: 18

Page Numbers: 369-76

Journal Abbreviation: J. Am. Soc. Mass Spectrom.

ISSN: 1044-0305

DAY: 13

MONTH: 11

YEAR: 2006

A pulsed triple ionization source for sequential ion/ion reactions in an electrodynamic ion trap. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9010412

A pulsed triple ionization source for sequential ion/ion reactions in an electrodynamic ion trap. Keywords Mesh Terms:

KEYWORDS: Ubiquitin

MESH TERMS: chemistry

Chemical & Substance for Abstract: A pulsed triple ionization source for sequential ion/ion reactions in an electrodynamic ion trap. Information

Substance Name: Bradykinin

Registry Number: 58-82-2

Grant and Affiliation Information for A pulsed triple ionization source for sequential ion/ion reactions in an electrodynamic ion trap.

AFFILIATION: Department of Chemistry, Purdue University, West Lafayette, Indiana 47907-2084, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: GM 45372

ACRONYM: GM

MEDLINETA: J Am Soc Mass Spectrom

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

A pulsed triple ionization source for sequential ion/ion reactions in an electrodynamic ion trap Related Publications

• A pulsed triple ionization source for sequential ion/ion reactions in an electrodynamic ion trap.
• Activation of intact electron-transfer products of polypeptides and proteins in cation transmission mode ion/ion reactions.
• Alternately pulsed nanoelectrospray ionization/atmospheric pressure chemical ionization for ion/ion reactions in an electrodynamic ion trap.
• Bidirectional ion transfer between quadrupole arrays: MSn ion/ion reaction experiments on a quadrupole/time-of-flight tandem mass spectrometer.
• Effects of cation charge-site identity and position on electron-transfer dissociation of polypeptide cations.
• Electron Transfer Dissociation of iTRAQ Labeled Peptide Ions.
• Electron transfer dissociation of doubly sodiated glycerophosphocholine lipids.
• Electron transfer ion/ion reactions in a three-dimensional quadrupole ion trap: reactions of doubly and triply protonated peptides with SO2*-.
• Electron-transfer reagent anion formation via electrospray ionization and collision-induced dissociation.
• Evolution of Instrumentation for the Study of Gas-Phase Ion/Ion Chemistry via Mass Spectrometry.
• Gas-phase ion/ion reactions of multiply protonated polypeptides with metal containing anions.
• Gas-phase ion/ion reactions of transition metal complex cations with multiply charged oligodeoxynucleotide anions.
• Gas-phase peptide/protein cationizing agent switching via ion/ion reactions.
• Implementation of ion/ion reactions in a quadrupole/time-of-flight tandem mass spectrometer.
• Ion trap collision-induced dissociation of human hemoglobin alpha-chain cations.
• Ion trap collisional activation of c and z* ions formed via gas-phase ion/ion electron-transfer dissociation.
• Ion/molecule reactions of cation radicals formed from protonated polypeptides via gas-phase ion/ion electron transfer.
• On the Value of Knowing a z* Ion for What It Is.
• Phosphopeptide anion characterization via sequential charge inversion and electron-transfer dissociation.
• Protein identification via ion-trap collision-induced dissociation and examination of low-mass product ions.
• Rapidly alternating transmission mode electron-transfer dissociation and collisional activation for the characterization of polypeptide ions.
• Relative information content and top-down proteomics by mass spectrometry: utility of ion/ion proton-transfer reactions in electrospray-based approaches.
• Selective disulfide bond cleavage in gold(I) cationized polypeptide ions formed via gas-phase ion/ion cation switching.
• Transmission mode ion/ion electron-transfer dissociation in a linear ion trap.
• Transmission mode ion/ion proton transfer reactions in a linear ion trap.