A proteomic approach to study Salmonella enterica serovar Typhimurium putative transporter YjeH associated with ceftriaxone resistance.

A proteomic approach to study Salmonella enterica serovar Typhimurium putative transporter YjeH associated with ceftriaxone resistance. Research Abstract Details 

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A proteomic approach to study Salmonella enterica serovar Typhimurium putative transporter YjeH associated with ceftriaxone resistance. Abstract Text:

Wensi S Hu,Yin-Hung Lin,Chun-Chieh Shih,

Mutant 6B7 of Salmonella enterica serovar Typhimurium has a transposon inserted in the putative transporter gene yjeH and shows a more-than-fourfold reduction in resistance to ceftriaxone. In this report we have used proteomic analysis to compare outer membrane protein profiles between this mutant and its parental strain R200. Five identified proteins were found to be altered. Of these proteins, the level of expression of the porin OmpD was increased and those of the putative outer membrane proteins STM1530 and STM3031, a subunit of the proton-pumping oxidoreductase NuoB and the heat shock protein MopA were decreased in 6B7 strain. Although the function of the yjeH gene remains unknown, a complementation assay suggested that the OmpD, STM1530, STM3031, NuoB, and MopA proteins are associated with ceftriaxone resistance and the expression of these proteins is influenced by the putative transporter gene yjeH in S. enterica serovar Typhimurium.

A proteomic approach to study Salmonella enterica serovar Typhimurium putative transporter YjeH associated with ceftriaxone resistance. Publishing Authors By Initials

WS Hu,YH Lin,CC Shih,

For similar bacteria: gram-negative bacteria: gram-negative facultatively anaerobic rods: enterobacteriaceae: salmonella: salmonella enterica: salmonella typhimurium research abstracts see: bacteria: gram-negative bacteria: gram-negative facultatively anaerobic rods: enterobacteriaceae: salmonella: salmonella enterica: salmonella typhimurium research

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A proteomic approach to study Salmonella enterica serovar Typhimurium putative transporter YjeH associated with ceftriaxone resistance. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Biochemical and biophysical research communication

VOLUME: 361

Page Numbers: 694-9

Journal Abbreviation: Biochem. Biophys. Res. Commun.

ISSN: 0006-291X

DAY: 25

MONTH: 07

YEAR: 2007

A proteomic approach to study Salmonella enterica serovar Typhimurium putative transporter YjeH associated with ceftriaxone resistance. Information

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LANGUAGE: eng

NlmUniqueID: 372516

A proteomic approach to study Salmonella enterica serovar Typhimurium putative transporter YjeH associated with ceftriaxone resistance. Keywords Mesh Terms:

KEYWORDS: Salmonella typhimurium

MESH TERMS: metabolism

Chemical & Substance for Abstract: A proteomic approach to study Salmonella enterica serovar Typhimurium putative transporter YjeH associated with ceftriaxone resistance. Information

Substance Name: Ceftriaxone

Registry Number: 73384-59-5

Grant and Affiliation Information for A proteomic approach to study Salmonella enterica serovar Typhimurium putative transporter YjeH associated with ceftriaxone resistance.

AFFILIATION: Institute of Biotechnology in Medicine, School of Medical Technology and Engineering, National Yang-Ming University, 155, Li-Nong St., Sec. 2, Peitou, Taipei, Taiwan. huws@ym.edu.tw

Country: United States

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MEDLINETA: Biochem Biophys Res Commun

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