A proteomic analysis reveals the loss of expression of the cell death regulatory gene GRIM-19 in human renal cell carcinomas.

A proteomic analysis reveals the loss of expression of the cell death regulatory gene GRIM-19 in human renal cell carcinomas. Research Abstract Details 

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A proteomic analysis reveals the loss of expression of the cell death regulatory gene GRIM-19 in human renal cell carcinomas. Abstract Text:

I Alchanati,S C Nallar,P Sun,L Gao,J Hu,A Stein,E Yakirevich,D Konforty,I Alroy,X Zhao,S P Reddy,M B Resnick,D V Kalvakolanu,I Alchanati,S C Nallar,P Sun,L Gao,J Hu,A Stein,E Yakirevich,D Konforty,I Alroy,X Zhao,S P Reddy,M B Resnick,D V Kalvakolanu,

Gene associated with retinoid interferon-induced mortality (GRIM)-19, an inhibitor of transcription factor STAT3, was originally identified as a critical regulatory protein in a genetic screen that was designed to identify the gene products necessary for Interferon (IFN)-beta- and retinoic acid-induced cell death. Over expression of GRIM-19 activates cell death. Conversely, inactivation of its expression promotes cell growth. STAT3 is a transcription factor that regulates gene expression in response to multiple extra cellular growth factors. In contrast to its normal feedback inhibition, a constitutive activation of STAT3 has been documented in several tumors. Although many STAT3-inhibitors are described, their relevance to human cancer is unclear. In an attempt to define the molecular alterations associated with human renal cell carcinoma (RCC) using mass spectrometry, we have discovered that expression of GRIM-19 is lost or severely depressed in a number of primary RCC and in some urinogenital tumors. Using an RCC cell line, we show that down regulation of GRIM-19 promotes tumor growth via an augmentation of STAT3-dependent gene expression. These studies for the first time show a tumor-suppressor like activity of GRIM-19.

A proteomic analysis reveals the loss of expression of the cell death regulatory gene GRIM-19 in human renal cell carcinomas. Publishing Authors By Initials

I Alchanati,SC Nallar,P Sun,L Gao,J Hu,A Stein,E Yakirevich,D Konforty,I Alroy,X Zhao,SP Reddy,MB Resnick,DV Kalvakolanu,I Alchanati,SC Nallar,P Sun,L Gao,J Hu,A Stein,E Yakirevich,D Konforty,I Alroy,X Zhao,SP Reddy,MB Resnick,DV Kalvakolanu,

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A proteomic analysis reveals the loss of expression of the cell death regulatory gene GRIM-19 in human renal cell carcinomas. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Oncogene

VOLUME: 25

Page Numbers: 7138-47

Journal Abbreviation: Oncogene

ISSN: 0950-9232

DAY: 29

MONTH: 05

YEAR: 2006

A proteomic analysis reveals the loss of expression of the cell death regulatory gene GRIM-19 in human renal cell carcinomas. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8711562

A proteomic analysis reveals the loss of expression of the cell death regulatory gene GRIM-19 in human renal cell carcinomas. Keywords Mesh Terms:

KEYWORDS: Reverse Transcriptase Polymerase Chain R

MESH TERMS: analysis

Chemical & Substance for Abstract: A proteomic analysis reveals the loss of expression of the cell death regulatory gene GRIM-19 in human renal cell carcinomas. Information

Substance Name: GRIM19 protein, human

Registry Number: EC 1.6.5.-

Grant and Affiliation Information for A proteomic analysis reveals the loss of expression of the cell death regulatory gene GRIM-19 in human renal cell carcinomas.

AFFILIATION: Proteologics Limited, Weizmann Science Park, Rehovot, Israel.

Country: England

AGENCY: United States NHLBI

GRANT: HL66109

ACRONYM: HL

MEDLINETA: Oncogene

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