A prospective study of inflammatory cytokines and diabetes mellitus in a multiethnic cohort of postmenopausal women.

A prospective study of inflammatory cytokines and diabetes mellitus in a multiethnic cohort of postmenopausal women. Research Abstract Details 

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A prospective study of inflammatory cytokines and diabetes mellitus in a multiethnic cohort of postmenopausal women. Abstract Text:

Simin Liu,Lesley Tinker,Yiqing Song,Nader Rifai,Denise E Bonds,Nancy R Cook,Gerardo Heiss,Barbara V Howard,Gokhan S Hotamisligil,Frank B Hu,Lewis H Kuller,JoAnn E Manson,

BACKGROUND: Inflammatory cytokines, including tumor necrosis factor alpha, IL-6 (interleukin 6), and high-sensitivity C-reactive protein (hsCRP), have been related to both insulin resistance and type 2 diabetes mellitus. However, prospective studies that comprehensively assess their roles in the development of type 2 diabetes are few, especially in minority populations. METHODS: Among 82,069 postmenopausal women aged 50 to 79 years without cardiovascular disease or diabetes mellitus who participated in the Women's Health Initiative Observational Study, we prospectively examined the relationships of plasma levels of tumor necrosis factor alpha receptor 2, IL-6, and hsCRP to diabetes risk. During a median follow-up period of 5.9 years, 1584 women who had clinical diabetes were matched by age, ethnicity, clinical center, time of blood draw, and duration of follow-up to 2198 study participants who were free of the disease. RESULTS: After adjustment for matching factors and known diabetes risk factors, all 3 markers were significantly associated with increased diabetes risk; the estimated relative risks comparing the highest with the lowest quartiles were 1.47 (95% confidence interval [CI], 1.10-1.97) for tumor necrosis factor alpha receptor 2, 3.08 (95% CI, 2.25-4.23) for IL-6, and 3.46 (95% CI, 2.50-4.80) for hsCRP (P for trend, <.01 for all biomarkers). When mutually adjusted, IL-6 and hsCRP remained significant in each ethnic group. While no statistically significant interactions were observed between ethnicity and these biomarkers on diabetes risk, there were consistent trends for the associations of hsCRP and IL-6 with increased diabetes risk in all ethnic groups. CONCLUSION: These prospective data showed that elevated levels of IL-6 and hsCRP were consistently and significantly associated with an increased risk of clinical diabetes in postmenopausal women.

A prospective study of inflammatory cytokines and diabetes mellitus in a multiethnic cohort of postmenopausal women. Publishing Authors By Initials

S Liu,L Tinker,Y Song,N Rifai,DE Bonds,NR Cook,G Heiss,BV Howard,GS Hotamisligil,FB Hu,LH Kuller,JE Manson,

For similar peptides: intercellular signaling peptides and proteins: cytokines: monokines: tumor necrosis factor-alpha research abstracts see: peptides: intercellular signaling peptides and proteins: cytokines: monokines: tumor necrosis factor-alpha research

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A prospective study of inflammatory cytokines and diabetes mellitus in a multiethnic cohort of postmenopausal women. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Archives of internal medicine

VOLUME: 167

Page Numbers: 1676-85

Journal Abbreviation: Arch. Intern. Med.

ISSN: 0003-9926

DAY: 3

MONTH: 12

YEAR: 2007

A prospective study of inflammatory cytokines and diabetes mellitus in a multiethnic cohort of postmenopausal women. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 372440

A prospective study of inflammatory cytokines and diabetes mellitus in a multiethnic cohort of postmenopausal women. Keywords Mesh Terms:

KEYWORDS: Tumor Necrosis Factor-alpha

MESH TERMS: blood

Chemical & Substance for Abstract: A prospective study of inflammatory cytokines and diabetes mellitus in a multiethnic cohort of postmenopausal women. Information

Substance Name: C-Reactive Protein

Registry Number: 9007-41-4

Grant and Affiliation Information for A prospective study of inflammatory cytokines and diabetes mellitus in a multiethnic cohort of postmenopausal women.

AFFILIATION: Department of Epidemiology, University of California, Los Angeles, CA 90095-1772, USA. siminliu@ucla.edu

Country: United States

AGENCY: United States NIDDK

GRANT: R01 DK062290

ACRONYM: DK

MEDLINETA: Arch Intern Med

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