A prospective investigation of major depressive disorder and comorbidity in abused and neglected children grown up.

A prospective investigation of major depressive disorder and comorbidity in abused and neglected children grown up. Research Abstract Details 

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A prospective investigation of major depressive disorder and comorbidity in abused and neglected children grown up. Abstract Text:

Cathy Spatz Widom,Kimberly DuMont,Sally J Czaja,

CONTEXT: Few prospective longitudinal studies have examined the relationship between abuse or neglect in childhood and depression in adulthood. OBJECTIVE: To determine whether abused and neglected children were at elevated risk of major depressive disorder (MDD) and psychiatric comorbidity, compared with matched control subjects, when followed up into young adulthood. DESIGN: Prospective cohort design study. SETTING: Midwestern metropolitan county area. PARTICIPANTS: Children with substantiated cases of physical and sexual abuse and neglect (before the age of 11 years) from January 1, 1967, to December 31, 1971 (n = 676) were matched based on age, race, sex, and approximate family social class with a group of non-abused and non-neglected children (n = 520) and followed up into young adulthood (mean age, 28.7 years). MAIN OUTCOME MEASURES: Between October 20, 1989, and December 22, 1995, 2-hour in-person interviews were conducted, using the National Institute of Mental Health Diagnostic Interview Schedule, Version III Revised, to determine DSM-III-R MDD and other psychiatric diagnoses. RESULTS: Child abuse and neglect were associated with an increased risk for current MDD (odds ratio [OR], 1.51; 95% confidence interval [CI], 1.06-2.14; P< or=.05) in young adulthood. Children who were physically abused (OR, 1.59; 95% CI, 1.00-2.52; P< or =.05) or experienced multiple types of abuse (OR, 1.75; 95% CI, 1.01-3.02; P< or =.05) were at increased risk of lifetime MDD, whereas neglect increased risk for current MDD (OR, 1.59; 95% CI, 1.10-2.29; P<.01). Childhood sexual abuse was not associated with elevated risk of MDD. Kaplan-Meier age-of-onset curves (log-rank statistic, 4.03; df = 1; P=.04) showed earlier onset of MDD for abused and neglected children compared with controls. Among those with MDD, comorbidity was higher for abused and neglected individuals than for controls. CONCLUSION: These results support the need for clinicians to increase efforts to detect and treat depression in physically abused and neglected children.

A prospective investigation of major depressive disorder and comorbidity in abused and neglected children grown up. Publishing Authors By Initials

CS Widom,K DuMont,SJ Czaja,

For similar investigative techniques: epidemiologic methods: statistics as topic: survival analysis research abstracts see: investigative techniques: epidemiologic methods: statistics as topic: survival analysis research

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A prospective investigation of major depressive disorder and comorbidity in abused and neglected children grown up. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Archives of general psychiatry

VOLUME: 64

Page Numbers: 49-56

Journal Abbreviation: Arch. Gen. Psychiatry

ISSN: 0003-990X

DAY: 3

MONTH: Jan

YEAR: 2007

A prospective investigation of major depressive disorder and comorbidity in abused and neglected children grown up. Information

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LANGUAGE: eng

NlmUniqueID: 372435

A prospective investigation of major depressive disorder and comorbidity in abused and neglected children grown up. Keywords Mesh Terms:

KEYWORDS: Survival Analysis

MESH TERMS: statistics & numerical data

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Grant and Affiliation Information for A prospective investigation of major depressive disorder and comorbidity in abused and neglected children grown up.

AFFILIATION: Department of Psychiatry, New Jersey Medical School, University of Medicine & Dentistry of New Jersey, 183 S. Orange Avenue, Newark, NJ 07103, USA. widomca@umdnj.edu

Country: United States

AGENCY: United States NIMH

GRANT: MH 58386

ACRONYM: MH

MEDLINETA: Arch Gen Psychiatry

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