A prospective evaluation of a quantitative D-dimer assay in the evaluation of acute pulmonary embolism.

A prospective evaluation of a quantitative D-dimer assay in the evaluation of acute pulmonary embolism. Research Abstract Details 

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A prospective evaluation of a quantitative D-dimer assay in the evaluation of acute pulmonary embolism. Abstract Text:

Lana K Hirai,Jayme M Takahashi,Hyo-Chun Yoon,Lana K Hirai,Jayme M Takahashi,Hyo-Chun Yoon,

PURPOSE: A prospective study was designed to determine if a screening quantitative serum D-dimer measurement of 1.0 microg/mL or less precludes pulmonary computed tomographic (CT) angiography in patients with possible acute pulmonary embolism (PE). MATERIALS AND METHODS: Over a period of 16 months, every patient seen in the emergency department in whom there was clinical suspicion of PE sufficient to warrant pulmonary CT angiography was also requested to have a quantitative serum D-dimer level measurement taken. All pulmonary CT angiography procedures were performed on a four-slice scanner and every examination was overread by a radiologist who was blinded to the D-dimer assay results. Three-month medical record and telephone follow-up was carried out for all participants who had a serum D-dimer level of 1.0 microg/mL or less to verify no new diagnosis or death from PE. RESULTS: In this prospective study, 361 consecutive patients who received pulmonary CT angiography had a D-dimer level of 1.0 microg/mL or less. There were 310 patients who had negative pulmonary CT angiography results and 50 patients who had indeterminate CT angiography results. Only one patient had positive pulmonary CT angiography findings. Minimum 3-month follow-up information was available for 349 patients, none of whom reported subsequent PE, including those with indeterminate pulmonary CT angiography results. CONCLUSION: The use of a screening D-dimer measurement of 1.0 microg/mL or less precludes pulmonary CT angiography in patients with possible acute PE. The use of this quantitative D-dimer assay would decrease radiation exposure, contrast medium toxicity, cost, and time for patients seen in the emergency medicine department.

A prospective evaluation of a quantitative D-dimer assay in the evaluation of acute pulmonary embolism. Publishing Authors By Initials

LK Hirai,JM Takahashi,HC Yoon,LK Hirai,JM Takahashi,HC Yoon,

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A prospective evaluation of a quantitative D-dimer assay in the evaluation of acute pulmonary embolism. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of vascular and interventional radiology :

VOLUME: 18

Page Numbers: 970-4

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ISSN: 1051-0443

DAY: 6

MONTH: Aug

YEAR: 2007

A prospective evaluation of a quantitative D-dimer assay in the evaluation of acute pulmonary embolism. Information

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LANGUAGE: eng

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Grant and Affiliation Information for A prospective evaluation of a quantitative D-dimer assay in the evaluation of acute pulmonary embolism.

AFFILIATION: John A. Burns School of Medicine, Kaiser Foundation Hospital, 3288 Moanalua Road, Honolulu, Hawaii 96819, USA.

Country: United States

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MEDLINETA: J Vasc Interv Radiol

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