A proposal for the mechanism-of-action of diazoparaquinone natural products.

A proposal for the mechanism-of-action of diazoparaquinone natural products. Research Abstract Details 

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A proposal for the mechanism-of-action of diazoparaquinone natural products. Abstract Text:

Ken S Feldman,Kyle J Eastman,

Treatment of the representative diazoparaquinone prekinamycin dimethyl ether with Bu3SnH/AIBN in aromatic solvents furnishes moderate-to-good yields of formal aryl adducts wherein a molecule of solvent is attached to the carbon (C(11)) previously bearing the diazo function. Substituent studies provide evidence in support of a radical aromatic substitution mechanism, in which radical addition to the diazoparaquinone function generates an intermediate C(11) vinylic radical.

A proposal for the mechanism-of-action of diazoparaquinone natural products. Publishing Authors By Initials

KS Feldman,KJ Eastman,

For similar organic chemicals: quinones research abstracts see: organic chemicals: quinones research

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A proposal for the mechanism-of-action of diazoparaquinone natural products. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of the American Chemical Society

VOLUME: 127

Page Numbers: 15344-5

Journal Abbreviation: J. Am. Chem. Soc.

ISSN: 0002-7863

DAY: 9

MONTH: Nov

YEAR: 2005

A proposal for the mechanism-of-action of diazoparaquinone natural products. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7503056

A proposal for the mechanism-of-action of diazoparaquinone natural products. Keywords Mesh Terms:

KEYWORDS: Quinones

MESH TERMS: pharmacology

Chemical & Substance for Abstract: A proposal for the mechanism-of-action of diazoparaquinone natural products. Information

Substance Name: DNA

Registry Number: 9007-49-2

Grant and Affiliation Information for A proposal for the mechanism-of-action of diazoparaquinone natural products.

AFFILIATION: Department of Chemistry, The Pennsylvania State University, University Park, PA 16802, USA. ksf@chem.psu.edu

Country: United States

AGENCY: United States NIGMS

GRANT: GM 37681

ACRONYM: GM

MEDLINETA: J Am Chem Soc

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