A preliminary randomized, double-blind, placebo-controlled study of the safety and efficacy of ondansetron in the treatment of cocaine dependence.

A preliminary randomized, double-blind, placebo-controlled study of the safety and efficacy of ondansetron in the treatment of cocaine dependence. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

A preliminary randomized, double-blind, placebo-controlled study of the safety and efficacy of ondansetron in the treatment of cocaine dependence. Abstract Text:

Bankole A Johnson,John D Roache,Nassima Ait-Daoud,Martin A Javors,Joseph M Harrison,Ahmed Elkashef,Jurij Mojsiak,Shou-Hua Li,Daniel A Bloch,

Prior studies have demonstrated inefficacy among dopamine receptor antagonists for treating cocaine dependence. An alternative approach would be to investigate the ability of indirect inhibitors of cortico-mesolimbic dopamine release, such as the 5-HT(3) receptor antagonist ondansetron, to reduce cocaine's reinforcing effects. We hypothesized that ondansetron might be more efficacious than placebo at reducing cocaine intake and promoting abstinence in cocaine-dependent individuals. In a pilot randomized, double-blind, 10-week controlled trial, 63 treatment-seeking, cocaine-dependent men and women received ondansetron (0.25 mg, 1.0 mg, or 4.0 mg twice daily) or placebo. Up to three times per week, participants were assessed on several measures of cocaine use, including urine benzoylecgonine. Cognitive behavioral therapy was administered weekly. Ondansetron was well tolerated, causing no serious adverse events. The ondansetron 4.0 mg group had the lowest dropout rate among all treatment groups and a greater rate of improvement in percentage of participants with a cocaine-free week compared with the placebo group (p = 0.02), whereas the ondansetron 1.0 mg group had a lower rate of improvement in percentage of weekly mean non-use days than did placebo recipients (p = 0.04). These results suggest the possibility of a non-linear dose-response function, with evidence supporting efficacy for the 4.0 mg group.

A preliminary randomized, double-blind, placebo-controlled study of the safety and efficacy of ondansetron in the treatment of cocaine dependence. Publishing Authors By Initials

BA Johnson,JD Roache,N Ait-Daoud,MA Javors,JM Harrison,A Elkashef,J Mojsiak,SH Li,DA Bloch,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

A preliminary randomized, double-blind, placebo-controlled study of the safety and efficacy of ondansetron in the treatment of cocaine dependence. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Drug and alcohol dependence

VOLUME: 84

Page Numbers: 256-63

Journal Abbreviation:

ISSN: 0376-8716

DAY: 2

MONTH: 05

YEAR: 2006

A preliminary randomized, double-blind, placebo-controlled study of the safety and efficacy of ondansetron in the treatment of cocaine dependence. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7513587

A preliminary randomized, double-blind, placebo-controlled study of the safety and efficacy of ondansetron in the treatment of cocaine dependence. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: A preliminary randomized, double-blind, placebo-controlled study of the safety and efficacy of ondansetron in the treatment of cocaine dependence. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for A preliminary randomized, double-blind, placebo-controlled study of the safety and efficacy of ondansetron in the treatment of cocaine dependence.

AFFILIATION: Department of Psychiatric Medicine, University of Virginia, P.O. Box 800623, Charlottesville, VA 22908-0623, USA. bankolejohnson@virginia.edu

Country: Ireland

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Drug Alcohol Depend

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

A preliminary randomized, double-blind, placebo-controlled study of the safety and efficacy of ondansetron in the treatment of cocaine dependence Related Publications

• A preliminary randomized, double-blind, placebo-controlled study of the safety and efficacy of ondansetron in the treatment of cocaine dependence.
• Abnormal expression of mu-crystallin in facioscapulohumeral muscular dystrophy.
• Absence of keratin 19 in mice causes skeletal myopathy with mitochondrial and sarcolemmal reorganization.
• Controlling for occasion-specific effects when assessing the test-retest reliability of self-report health questionnaires.
• Daytime Cheyne-Stokes respiration in ambulatory patients with severe congestive heart failure is associated with increased mortality.
• Delayed Recovery Of Skeletal Muscle Function In Dysferlin- deficient Mice Following Large-strain Lengthening Contractions: 1857: Board #145 May 31 9:00 AM - 10:30 AM.
• Demonstration of presence of acanthamoeba mitochondrial DNA in brain tissue and cerebrospinal fluid by PCR in samples from a patient who died of granulomatous amebic encephalitis.
• Different obscurin isoforms localize to distinct sites at sarcomeres.
• Disruption of nitric oxide synthase 3 protects against the cardiac injury, dysfunction, and mortality induced by doxorubicin.
• Extracorporeal circulation activates endothelial nitric oxide synthase in erythrocytes.
• Influence Of An Interdisciplinary Programme Adipocytokines And Insulin Resistance In Obese Children And Adolescence: 1502: Board #265 May 30 9:30 AM - 11:00 AM.
• Mapping the binding site on small ankyrin 1 for obscurin.
• Molecular and phylogenetic analyses reveal mammalian-like clockwork in the honey bee (Apis mellifera) and shed new light on the molecular evolution of the circadian clock.
• Obscurin: a multitasking muscle giant.
• Probing the mRNA processing body using protein macroarrays and "autoantigenomics".
• Substance abuse among medical practitioners.
• THE CONTRIBUTION OF MICROSCOPES TO THE STUDY OF LIVING CIRCULATION: NEWER METHODS FOR THE STUDY OF DYNAMIC EVENTS IN LIVING ORGANS.
• Tailoring peripartum nursing care for women of advanced maternal age.
• The actin binding domain of ACF7 binds directly to the tetratricopeptide repeat domains of rapsyn.
• The art of psychiatry.
• Transzygomatic approach to the tentorial incisura: surgical anatomy.
• Value of the 12-lead resting electrocardiogram for the diagnosis of previous myocardial infarction in paced patients.
• [A new operative procedure for the treatment of urinary incontinence]
• [Consequence of GKV-WSG for physicians' remuneration. Facts--analyses--perspectives]
• [Hemoptysis after subclavian vein puncture]
• [Modalities of the early development of the embryo and nidation in mammals]
• [On the problem of gland cells in the uterine muscles in women]
• [Studies on the influence of estrogen on ovum implantation in mice]
• [Treatment of so-called functional uterine hemorrhages]
• cGMP-dependent protein kinase I interacts with TRIM39R, a novel Rpp21 domain-containing TRIM protein.