A preliminary panorama of the diversity of N1 subtype influenza viruses.

A preliminary panorama of the diversity of N1 subtype influenza viruses. Research Abstract Details 

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A preliminary panorama of the diversity of N1 subtype influenza viruses. Abstract Text:

Ji-Ming Chen,Hong-Chao Ma,Ji-Wang Chen,Ying-Xue Sun,Jin-Ming Li,Zhi-Liang Wang,

N1 subtype influenza viruses have caused many epidemics and even a few pandemics in humans, pigs and fowls including 1918 human H1N1 pandemic, which killed 20-50 million people and the current avian H5N1 pandemic in the Eastern Hemisphere, which has caused great economic losses and posed a severe threat to human public health. To elucidate the whole diversity of N1 influenza viruses from a dynamic view, 202 neuraminidase (NA) sequences of N1 subtype influenza isolates were selected and analyzed in this study. Our results showed that N1 influenza isolates could be divided into three distinct lineages (Human, Classic Swine and Avian), which largely circulated in the humans, pigs and fowls respectively, though viruses in the Avian lineage could infect mammals and even there was a sublineage in the Avian lineage wholly isolated from pigs. The Avian lineage and the Human lineage, which have existed at least for decades, possibly began divergence around in 1890 through regression analysis. Both of the Human and Avian lineages could be further divided into some sublineages, and the correlation between these lineages (or sublineages) and their isolation places, isolation time, hemagglutinin (HA) subtypes, host species, virulence, or epidemics were discussed. The panorama of the diversity of N1 influenza viruses presented in this study provided a framework for the studies on the evolution and epidemiology of N1 influenza viruses.

A preliminary panorama of the diversity of N1 subtype influenza viruses. Publishing Authors By Initials

JM Chen,HC Ma,JW Chen,YX Sun,JM Li,ZL Wang,

For similar genetic phenomena: variation (genetics) research abstracts see: genetic phenomena: variation (genetics) research

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A preliminary panorama of the diversity of N1 subtype influenza viruses. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Virus genes

VOLUME: 35

Page Numbers: 33-40

Journal Abbreviation: Virus Genes

ISSN: 0920-8569

DAY: 4

MONTH: 10

YEAR: 2006

A preliminary panorama of the diversity of N1 subtype influenza viruses. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8803967

A preliminary panorama of the diversity of N1 subtype influenza viruses. Keywords Mesh Terms:

KEYWORDS: Variation (Genetics)

MESH TERMS: virology

Chemical & Substance for Abstract: A preliminary panorama of the diversity of N1 subtype influenza viruses. Information

Substance Name: Hemagglutinin Glycoproteins, Influenza V

Registry Number: 0

Grant and Affiliation Information for A preliminary panorama of the diversity of N1 subtype influenza viruses.

AFFILIATION: Chinese Center for Animal Health and Epidemiology, Nanjing Road 369, Qingdao, 266032, China. chenjiming2004@yahoo.com.cn

Country: United States

AGENCY: United States NHLBI

GRANT: T32-HL076139

ACRONYM: HL

MEDLINETA: Virus Genes

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