A preliminary, controlled investigation of magnesium L-aspartate hydrochloride for illicit cocaine and opiate use in methadone-maintained patients.

A preliminary, controlled investigation of magnesium L-aspartate hydrochloride for illicit cocaine and opiate use in methadone-maintained patients. Research Abstract Details 

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A preliminary, controlled investigation of magnesium L-aspartate hydrochloride for illicit cocaine and opiate use in methadone-maintained patients. Abstract Text:

Based on pre-clinical studies suggesting that magnesium (Mg) reduces cocaine self-administration and potentiates the antinociceptive effects of morphine, we conducted a preliminary randomized clinical trial investigating Mg for the treatment of illicit cocaine and opiate use. Eighteen methadone-maintained patients who used illicit opiates and cocaine received either Mg (732 mg/day) or placebo for 12 weeks. Overall, findings showed that the percentage of urine screens testing positive for opiates in the Mg group (22.6%) was half that of the placebo group (46.4%), p = .04; the difference was even greater in the "medication compliant" sample (Mg: 16.3%, placebo: 47.9%), p = .02. Cocaine craving was lower in the Mg compared to the placebo group, but there was no difference between groups in cocaine use. These preliminary findings suggest that Mg may have a beneficial effect for reducing illicit opiate use. It is possible that a higher dose of Mg than was used in this study may be needed to decrease cocaine use.

A preliminary, controlled investigation of magnesium L-aspartate hydrochloride for illicit cocaine and opiate use in methadone-maintained patients. Publishing Authors By Initials

For similar pharmaceutical preparations: street drugs research abstracts see: pharmaceutical preparations: street drugs research

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A preliminary, controlled investigation of magnesium L-aspartate hydrochloride for illicit cocaine and opiate use in methadone-maintained patients. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of addictive diseases

VOLUME: 22

Page Numbers: 49-61

Journal Abbreviation:

ISSN: 1055-0887

DAY: 12

MONTH: 05

YEAR: 2003

A preliminary, controlled investigation of magnesium L-aspartate hydrochloride for illicit cocaine and opiate use in methadone-maintained patients. Information

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LANGUAGE: eng

NlmUniqueID: 9107051

A preliminary, controlled investigation of magnesium L-aspartate hydrochloride for illicit cocaine and opiate use in methadone-maintained patients. Keywords Mesh Terms:

KEYWORDS: Street Drugs

MESH TERMS: rehabilitation

Chemical & Substance for Abstract: A preliminary, controlled investigation of magnesium L-aspartate hydrochloride for illicit cocaine and opiate use in methadone-maintained patients. Information

Substance Name: Methadone

Registry Number: 76-99-3

Grant and Affiliation Information for A preliminary, controlled investigation of magnesium L-aspartate hydrochloride for illicit cocaine and opiate use in methadone-maintained patients.

AFFILIATION: Yale University School of Medicine, Department of Psychiatry, Substance Abuse Center, New Haven, CT 06519, USA. arthur.margolin@yale.edu

Country: United States

AGENCY: United States NIDA

GRANT: DA00277

ACRONYM: DA

MEDLINETA: J Addict Dis

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