A Pre-RNA Candidate Revisited: Both Enantiomers of Flexible Nucleoside Triphosphates are DNA Polymerase Substrates.

A Pre-RNA Candidate Revisited: Both Enantiomers of Flexible Nucleoside Triphosphates are DNA Polymerase Substrates. Research Abstract Details 

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A Pre-RNA Candidate Revisited: Both Enantiomers of Flexible Nucleoside Triphosphates are DNA Polymerase Substrates. Abstract Text:

Benjamin D Heuberger,Christopher Switzer,Benjamin D Heuberger,Christopher Switzer,

One of the earliest proposed pre-RNA candidates is the flexible nucleic acid (FNA) structure based on the mixed acetal aminal of formyl glycerol. FNA achieves dramatic stereochemical simplification by formally deleting the 2'-CHOH group of RNA, thereby replacing the four RNA stereocenters with a single (pro)stereocenter. Despite the documented inability of FNA to form stable duplexes with DNA, flexible nucleoside triphosphates (fNTPs) are substrates for DNA polymerases. Consistent with early predictions, FNA chirality is unimportant as polymerases accept both (S)- and (R)-fNTP antipodes. These results provide a renewed basis for positing FNA as a viable informational molecule.

A Pre-RNA Candidate Revisited: Both Enantiomers of Flexible Nucleoside Triphosphates are DNA Polymerase Substrates. Publishing Authors By Initials

BD Heuberger,C Switzer,BD Heuberger,C Switzer,

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A Pre-RNA Candidate Revisited: Both Enantiomers of Flexible Nucleoside Triphosphates are DNA Polymerase Substrates. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of the American Chemical Society

VOLUME: 130

Page Numbers: 412-3

Journal Abbreviation: J. Am. Chem. Soc.

ISSN: 1520-5126

DAY: 21

MONTH: 12

YEAR: 2007

A Pre-RNA Candidate Revisited: Both Enantiomers of Flexible Nucleoside Triphosphates are DNA Polymerase Substrates. Information

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LANGUAGE: eng

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Grant and Affiliation Information for A Pre-RNA Candidate Revisited: Both Enantiomers of Flexible Nucleoside Triphosphates are DNA Polymerase Substrates.

AFFILIATION: Department of Chemistry, University of California-Riverside, Riverside, California 92521.

Country: United States

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MEDLINETA: J Am Chem Soc

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