A practical guide to robust detection of GABA in human brain by J-difference spectroscopy at 3 T using a standard volume coil.

A practical guide to robust detection of GABA in human brain by J-difference spectroscopy at 3 T using a standard volume coil. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

A practical guide to robust detection of GABA in human brain by J-difference spectroscopy at 3 T using a standard volume coil. Abstract Text:

Kevin W Waddell,Malcolm J Avison,James M Joers,John C Gore,Kevin W Waddell,Malcolm J Avison,James M Joers,John C Gore,

gamma-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter in human brain and has been implicated in several neuropsychiatric disorders. In vivo human brain GABA concentrations are near the detection limit for magnetic resonance spectroscopy ( approximately 1 mM), and because of overlap with more abundant compounds, spectral editing is generally necessary to detect GABA. In previous reports, GABA spectra edited by J-difference spectroscopy vary considerably in appearance. We have evaluated the factors that affect GABA spectra and the conditions necessary for robust acquisition of J-difference spectra from arbitrary brain regions. In particular, we demonstrate that variations in spectral quality can be explained in part by the incoherent addition of transients that results from shot to shot frequency and phase variations. An automated time-domain spectral alignment strategy that enables reproducible acquisition of high-quality GABA spectra at 3 T with a standard 30-cm T/R volume coil is presented. Representative GABA spectra from human frontal lobe, an area where susceptibility-induced frequency and phase variations are especially troublesome, that demonstrate the robustness of the acquisition and data handling strategy used in this study are presented.

A practical guide to robust detection of GABA in human brain by J-difference spectroscopy at 3 T using a standard volume coil. Publishing Authors By Initials

KW Waddell,MJ Avison,JM Joers,JC Gore,KW Waddell,MJ Avison,JM Joers,JC Gore,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

A practical guide to robust detection of GABA in human brain by J-difference spectroscopy at 3 T using a standard volume coil. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Magnetic resonance imaging

VOLUME: 25

Page Numbers: 1032-8

Journal Abbreviation:

ISSN: 0730-725X

DAY: 2

MONTH: 02

YEAR: 2007

A practical guide to robust detection of GABA in human brain by J-difference spectroscopy at 3 T using a standard volume coil. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8214883

A practical guide to robust detection of GABA in human brain by J-difference spectroscopy at 3 T using a standard volume coil. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: A practical guide to robust detection of GABA in human brain by J-difference spectroscopy at 3 T using a standard volume coil. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for A practical guide to robust detection of GABA in human brain by J-difference spectroscopy at 3 T using a standard volume coil.

AFFILIATION: Institute of Imaging Science, Vanderbilt University, Nashville, TN 37232-2675, USA. kevin.waddell@vanderbilt.edu

Country: United States

AGENCY: United States NIBIB

GRANT: EB0000461

ACRONYM: EB

MEDLINETA: Magn Reson Imaging

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

A practical guide to robust detection of GABA in human brain by J-difference spectroscopy at 3 T using a standard volume coil Related Publications

• A Phase II study of trabectedin single agent in patients with recurrent ovarian cancer previously treated with platinum-based regimens.
• A practical guide to robust detection of GABA in human brain by J-difference spectroscopy at 3 T using a standard volume coil.
• Adverse childhood experiences and mental health in young adults: a longitudinal survey.
• Amphibian emergency medicine.
• An Arabidopsis haplotype map takes root.
• Assessing functional connectivity in the human brain by fMRI.
• Assessing signal enhancement in distant dipolar field-based sequences.
• Calculation of RF Peak Power for 2D Arbitrary Shape Excitation in MRI.
• Comment on "Assessing functional connectivity in the human brain by fMRI".
• Comparison of a reference region model with direct measurement of an AIF in the analysis of DCE-MRI data.
• Detection and isolation of Japanese encephalitis virus from blood clots collected during the acute phase of infection.
• Development of 2dTCA for the detection of irregular, transient bold activity.
• Development of left occipitotemporal systems for skilled reading in children after a phonologically- based intervention.
• Effects of hypoglycemia on human brain activation measured with fMRI.
• Estrogenic environmental endocrine-disrupting chemical effects on reproductive neuroendocrine function and dysfunction across the life cycle.
• Hypoglycemia reduces the blood-oxygenation level dependent signal in primary auditory and visual cortex: a functional magnetic resonance imaging study.
• Integrating spatially resolved three-dimensional MALDI IMS with in vivo magnetic resonance imaging.
• Integration of quantitative DCE-MRI and ADC mapping to monitor treatment response in human breast cancer: initial results.
• Long-term trends in the use of coronary reperfusion strategies in acute myocardial infarction: a community-wide perspective.
• Molecular imaging of vascular endothelial growth factor receptor 2 expression using targeted contrast-enhanced high-frequency ultrasonography.
• Novel localization of NMDA receptors within neuroendocrine gonadotropin-releasing hormone terminals.
• Numerical study of water diffusion in biological tissues using an improved finite difference method.
• Optimization of MAGIC gel formulation for three-dimensional radiation therapy dosimetry.
• Quantitative magnetization transfer imaging via selective inversion recovery with short repetition times.
• Randomized adjuvant therapy trials in melanoma: surgical and systemic.
• Repeatability of a reference region model for analysis of murine DCE-MRI data at 7T.
• Serum glucose levels and hospital outcomes in patients with acute myocardial infarction without prior diabetes: a community-wide perspective.
• The effects of prenatal PCBs on adult female paced mating reproductive behaviors in rats.
• Tracking the migration of dendritic cells by in vivo optical imaging.
• Why endocrinologists need to take ownership of endocrine disruption.