A potential role for bone morphogenetic protein signalling in glial cell fate determination following adult central nervous system injury in vivo.

A potential role for bone morphogenetic protein signalling in glial cell fate determination following adult central nervous system injury in vivo. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

A potential role for bone morphogenetic protein signalling in glial cell fate determination following adult central nervous system injury in vivo. Abstract Text:

David W Hampton,Richard A Asher,Toru Kondo,John D Steeves,Matt S Ramer,James W Fawcett,David W Hampton,Richard A Asher,Toru Kondo,John D Steeves,Matt S Ramer,James W Fawcett,

Bone morphogenetic proteins (BMPs) and their endogenous inhibitors, including noggin, chordin and follistatin, have roles in pattern formation and fate specification of neuronal and glial cells during nervous system development. We have examined their influence on glial reactions in the injured central nervous system (CNS). We show that penetrating injuries to the brain and spinal cord resulted in the upregulation of BMP-2/4, BMP-7, and noggin, with the latter being expressed almost exclusively by reactive astrocytes at the injury site, and we show that astrocytes in vitro produce noggin. As BMPs have been shown to drive cultured NG2-positive oligodendrocyte precursors (OPCs) towards a multipotential phenotype (type II astrocytes), we investigated the effects of inhibiting noggin with a function-blocking antibody (noggin-FbAb). In vitro, BMP-driven conversion of OPCs to type 2 astrocytes was inhibited by noggin, an effect that was reversed by noggin-FbAb. Noggin-FbAb also increased the number of type 2 astrocytes generated from cultured OPCs exposed to an astrocyte feeder layer, consistent with astrocytes producing both BMPs and noggin. In knife cut injuries in vivo, noggin-FbAb treatment resulted in an increase in the number of NG2-positive cells and small GFAP-positive cells in the injury site, and the appearance of glial cells with the morphological and antigenic characteristics of type 2 astrocytes (as generated in vitro), with coexpression of both GFAP and NG2. This potential conversion of inhibitory OPCs to type 2 astrocyte-like cells in vivo suggests that endogenous BMPs, unmasked by noggin antagonism, might be exploited to manipulate cell fate following CNS trauma.

A potential role for bone morphogenetic protein signalling in glial cell fate determination following adult central nervous system injury in vivo. Publishing Authors By Initials

DW Hampton,RA Asher,T Kondo,JD Steeves,MS Ramer,JW Fawcett,DW Hampton,RA Asher,T Kondo,JD Steeves,MS Ramer,JW Fawcett,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

A potential role for bone morphogenetic protein signalling in glial cell fate determination following adult central nervous system injury in vivo. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The European journal of neuroscience

VOLUME: 26

Page Numbers: 3024-35

Journal Abbreviation: Eur. J. Neurosci.

ISSN: 0953-816X

DAY: 21

MONTH: Dec

YEAR: 2007

A potential role for bone morphogenetic protein signalling in glial cell fate determination following adult central nervous system injury in vivo. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8918110

A potential role for bone morphogenetic protein signalling in glial cell fate determination following adult central nervous system injury in vivo. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: A potential role for bone morphogenetic protein signalling in glial cell fate determination following adult central nervous system injury in vivo. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for A potential role for bone morphogenetic protein signalling in glial cell fate determination following adult central nervous system injury in vivo.

AFFILIATION: ICORD, University of British Columbia, Vancouver, BC, Canada, and Cambridge Centre for Brain Repair, University of Cambridge, ED Adrian Building, Forvie Site, Robinson Way, Cambridge CB2 2PY, UK.

Country: France

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Eur J Neurosci

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

A potential role for bone morphogenetic protein signalling in glial cell fate determination following adult central nervous system injury in vivo Related Publications

• A comparative view of sperm ultrastructure.
• A potential role for bone morphogenetic protein signalling in glial cell fate determination following adult central nervous system injury in vivo.
• A risk score for predicting perioperative blood transfusion in liver surgery (Br J Surg 2007; 94: 860-865).
• A selective tachykinin receptor agonist promotes differentiation but not survival of rat chromaffin cells in vitro.
• Allergic contact dermatitis from 4-chloro-2-[methylthio]pyrimidine-5-carboxylic acid ethyl ester and methyl 4-hydroxy-2-hexynoate in a laboratory chemist.
• Antidepressants: partial response in chronic depression.
• Case of rupture of left lower-lobe bronchus with recovery.
• Chondroitinase ABC has a long-lasting effect on chondroitin sulphate glycosaminoglycan content in the injured rat brain.
• Commentary on Hsu L-L (2006) An analysis of clinical teacher behaviour in a nursing practicum in Taiwan. Journal of Clinical Nursing 15, 619-628.
• Drug nephrotoxicity--the significance of cellular mechanisms.
• Expression, Activity and Regulation of CYP3A in Human and Rodent Brain.
• Factors affecting morphine metabolism following major liver resection.
• Gametogenesis in the male: prospects for its control.
• General practitioners and psychological medicine. Their views on a postgraduate course.
• Heparan sulphate proteoglycans in glia and in the normal and injured CNS: expression of sulphotransferases and changes in sulphation.
• Hereditary painful callosities.
• In response to: Fu M.R., McDaniel R.W. & Rhodes V.A. (2007) Measuring symptom occurrence and symptom distress: development of the Symptom Distress Index. Journal of Advanced Nursing 59, 623-634.
• Infection control. An outbreak of innovation.
• Microchannels as axonal amplifiers.
• Modeling scattering from azimuthally symmetric bathymetric features using wavefield superposition.
• Nursing qua nursing: the connection between nursing knowledge and nursing shortages.
• Observations on the blood supply of growing antlers.
• On 'evidence-based practice': purpose of research is to develop theory.
• Repair in the central nervous system.
• Restricted primitive model for electrolyte solutions in contact with solid surface modified by grafted chains: A density functional approach.
• Series approach to modeling ion size effects for asymmetric electrolytes in the diffuse double layer.
• The added value of nursing conceptual model-based research.
• The role of massage therapy in the relief of cancer pain.
• The specificity of the response of preoptic-septal area neurons to estrogen: 17alpha-estradiol versus 17beta-estradiol and the response of extrahypothalamic neurons.
• The use of chewing gum for preventing postoperative ileus.