A potent transactivation domain mimic with activity in living cells.

A potent transactivation domain mimic with activity in living cells. Research Abstract Details 

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A potent transactivation domain mimic with activity in living cells. Abstract Text:

Bo Liu,Prasanna G Alluri,Peng Yu,Thomas Kodadek,

Transcriptional coactivator-binding peptoids were isolated from a large combinatorial library. One of these molecules is shown to function as a potent activation domain surrogate in mammalian cells. Up to a 900-fold increase in expression of a Gal4-responsive reporter gene is observed when a steroid conjugate of the peptoid is incubated with HeLa cells expressing a Gal4 DNA-binding domain (DBD)-glucocorticoid receptor ligand-binding domain (GRLBD) fusion protein.

A potent transactivation domain mimic with activity in living cells. Publishing Authors By Initials

B Liu,PG Alluri,P Yu,T Kodadek,

For similar proteins: dna-binding proteins: trans-activators research abstracts see: proteins: dna-binding proteins: trans-activators research

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MEDLINE DATE:

A potent transactivation domain mimic with activity in living cells. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of the American Chemical Society

VOLUME: 127

Page Numbers: 8254-5

Journal Abbreviation: J. Am. Chem. Soc.

ISSN: 0002-7863

DAY: 15

MONTH: Jun

YEAR: 2005

A potent transactivation domain mimic with activity in living cells. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7503056

A potent transactivation domain mimic with activity in living cells. Keywords Mesh Terms:

KEYWORDS: Trans-Activators

MESH TERMS: metabolism

Chemical & Substance for Abstract: A potent transactivation domain mimic with activity in living cells. Information

Substance Name: CREB-Binding Protein

Registry Number: EC 2.3.1.48

Grant and Affiliation Information for A potent transactivation domain mimic with activity in living cells.

AFFILIATION: Departments of Internal Medicine and Molecular Biology and Center for Biomedical Inventions, University of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.

Country: United States

AGENCY: United States NIDDK

GRANT: P01 DK 58398

ACRONYM: DK

MEDLINETA: J Am Chem Soc

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