A population study of neutering status as a risk factor for canine prostate cancer.

A population study of neutering status as a risk factor for canine prostate cancer. Research Abstract Details 

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A population study of neutering status as a risk factor for canine prostate cancer. Abstract Text:

Jeffrey N Bryan,Matthew R Keeler,Carolyn J Henry,Margaret E Bryan,Allen W Hahn,Charles W Caldwell,

BACKGROUND: Prostate cancer has been reported to occur more commonly in neutered than intact male dogs in several case series. This study was undertaken to evaluate risk of prostate cancer in a large population database. The hypothesis was that castration is a risk factor for prostate cancer in male companion dogs. METHODS: Data were derived from recorded visits to North American veterinary teaching hospitals. The Veterinary Medical Databases (VMDB) were queried to yield male dogs with urinary bladder transitional cell carcinoma (TCC), prostate adenocarcinoma (ACA), prostate TCC, prostate carcinoma (CA), and prostate tumors. A second query yielded all male dogs over the age of 4 years without a diagnosis of urinary tract cancer. These populations were compared to determine relative risks for developing each disease, singly and collectively, associated with neutering status. Odds ratios were calculated for breed as a risk factor. RESULTS: Neutered males had a significantly increased risk for each form of cancer. Neutered males had an odds ratio of 3.56 (3.02-4.21) for urinary bladder TCC, 8.00 (5.60-11.42) for prostate TCC, 2.12 (1.80-2.49) for prostate adenocarcinoma, 3.86 (3.13-4.16) for prostate carcinoma, and 2.84 (2.57-3.14) for all prostate cancers. Relative risks were highly similar when cases were limited to those with a histologically confirmed diagnosis. CONCLUSIONS: Breed predisposition suggests that genetic factors play a role in the development of prostate cancer. The risk associated with being neutered is highest for TCC, supporting previous work identifying the urothelium and ductular rather than acinar epithelium as the source of these tumors.

A population study of neutering status as a risk factor for canine prostate cancer. Publishing Authors By Initials

JN Bryan,MR Keeler,CJ Henry,ME Bryan,AW Hahn,CW Caldwell,

For similar neoplasms: neoplasms by site: urogenital neoplasms: urologic neoplasms: urinary bladder neoplasms research abstracts see: neoplasms: neoplasms by site: urogenital neoplasms: urologic neoplasms: urinary bladder neoplasms research

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A population study of neutering status as a risk factor for canine prostate cancer. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: The Prostate

VOLUME: 67

Page Numbers: 1174-81

Journal Abbreviation: Prostate

ISSN: 0270-4137

DAY: 1

MONTH: Aug

YEAR: 2007

A population study of neutering status as a risk factor for canine prostate cancer. Information

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LANGUAGE: eng

NlmUniqueID: 8101368

A population study of neutering status as a risk factor for canine prostate cancer. Keywords Mesh Terms:

KEYWORDS: Urinary Bladder Neoplasms

MESH TERMS: veterinary

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Grant and Affiliation Information for A population study of neutering status as a risk factor for canine prostate cancer.

AFFILIATION: Department of Veterinary Medicine and Surgery, University of Missouri, Columbia, Missouri, USA. bryanjn@missouri.edu

Country: United States

AGENCY: United States NLM

GRANT: T15-LM07089

ACRONYM: LM

MEDLINETA: Prostate

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