A population-based study in Ghana to investigate inter-individual variation in plasma t-PA and PAI-1.

A population-based study in Ghana to investigate inter-individual variation in plasma t-PA and PAI-1. Research Abstract Details 

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A population-based study in Ghana to investigate inter-individual variation in plasma t-PA and PAI-1. Abstract Text:

Scott M Williams,Shelli Stocki,Lan Jiang,Kwabena Brew,Seth Gordon,Douglas E Vaughan,Nancy J Brown,Kwabena A Poku,Jason H Moore,Scott M Williams,Shelli Stocki,Lan Jiang,Kwabena Brew,Seth Gordon,Douglas E Vaughan,Nancy J Brown,Kwabena A Poku,Jason H Moore,Scott M Williams,Shelli Stocki,Lan Jiang,Kwabena Brew,Seth Gordon,Douglas E Vaughan,Nancy J Brown,Kwabena A Poku,Jason H Moore,

INTRODUCTION: Susceptibility to arterial thrombosis has a significant genetic component that is partly due to the expression of two proteins, tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor-1 (PAI-1), that directly influence thrombus formation and degradation. We have initiated a large-scale population-based study to characterize the genetic architecture of plasma t-PA and PAI-1 in Blacks from Sunyani, Ghana. DESIGN: The design of the study is based on the recruitment of 2000 unrelated subjects who are ascertained without regard to chronic disease status. The analyses of the results will be done by dividing the data into two parts, a modeling set and a validation data set. This study design will facilitate the identification of genetic, environmental, and demographic factors that contribute to inter-individual variation in plasma levels of t-PA and PAI-1 in the population at-large. RESULTS: We report the specifics of the study design, as well as phenotype information on the first 1000 subjects. Our results show that females and males differ significantly in several key measures, including PAI-1, BMI, total cholesterol, and systolic blood pressure. CONCLUSIONS: The data collected from this population-based study demonstrate significant sex differences in PAI-1 and critical factors that may influence risk of thrombosis. These samples will serve to inform the genetic analyses of t-PA and PAI- levels.

A population-based study in Ghana to investigate inter-individual variation in plasma t-PA and PAI-1. Publishing Authors By Initials

SM Williams,S Stocki,L Jiang,K Brew,S Gordon,DE Vaughan,NJ Brown,KA Poku,JH Moore,SM Williams,S Stocki,L Jiang,K Brew,S Gordon,DE Vaughan,NJ Brown,KA Poku,JH Moore,SM Williams,S Stocki,L Jiang,K Brew,S Gordon,DE Vaughan,NJ Brown,KA Poku,JH Moore,

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A population-based study in Ghana to investigate inter-individual variation in plasma t-PA and PAI-1. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Ethnicity & disease

VOLUME: 17

Page Numbers: 492-7

Journal Abbreviation:

ISSN: 1049-510X

DAY: 7

MONTH: 11

YEAR: 2007

A population-based study in Ghana to investigate inter-individual variation in plasma t-PA and PAI-1. Information

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LANGUAGE: eng

NlmUniqueID: 9109034

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AFFILIATION: Center for Human Genetics Research, 519 Light Hall, Vanderbilt University Medical School, Nashville, TN 37232-0700, USA. smwilliams@chgr.mc.vanderbilt.edu

Country: United States

AGENCY: United States NHLBI

GRANT: HL65234

ACRONYM: HL

MEDLINETA: Ethn Dis

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