A population-based assessment of rates of bone loss at multiple skeletal sites: evidence for substantial trabecular bone loss in young adult women and men.

A population-based assessment of rates of bone loss at multiple skeletal sites: evidence for substantial trabecular bone loss in young adult women and men. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

A population-based assessment of rates of bone loss at multiple skeletal sites: evidence for substantial trabecular bone loss in young adult women and men. Abstract Text:

B Lawrence Riggs,L Joseph Melton,Richard A Robb,Jon J Camp,Elizabeth J Atkinson,Lisa McDaniel,Shreyasee Amin,Peggy A Rouleau,Sundeep Khosla,B Lawrence Riggs,L Joseph Melton,Richard A Robb,Jon J Camp,Elizabeth J Atkinson,Lisa McDaniel,Shreyasee Amin,Peggy A Rouleau,Sundeep Khosla,

Using QCT, we made a longitudinal, population-based assessment of rates of bone loss over life at the distal radius, distal tibia, and lumbar spine. Cortical bone loss began in perimenopause in women and later in life in men. In contrast, trabecular bone loss began in young adulthood in both sexes. Introduction: Although conventional wisdom holds that bone loss begins at menopause in women and later in life in men, this has not been examined longitudinally in population-based studies using precise technology capable of distinguishing cortical and trabecular bone. Materials and Methods: In an age- and sex-stratified population sample (n = 553), we measured volumetric BMD (vBMD) of trabecular and cortical bone by QCT annually for up to 3 yr at the distal radius (DR) and distal tibia (DT) (n = 552) and trabecular vBMD at baseline and 3 yr at the lumbar spine (LS) (n = 474). Results: Substantial cortical bone loss began in middle life in women but began mainly after age 75 in men. In contrast, substantial trabecular bone loss began in young adult women and men at all three skeletal sites and continued throughout life with acceleration during perimenopause in women. Women experienced 37% and men experienced 42% of their total lifetime trabecular bone loss before age 50 compared with 6% and 15%, respectively, for cortical bone. Median rates of change in trabecular bone (%/yr) were -0.40, -0.24, and -1.61 in young adult women and -0.38, -0.40, and -0.84 in young adult men at the DR, DT, and LS, respectively (all p < 0.001). The early trabecular bone loss did not consistently correlate with putative causal factors, except for a trend with IGF-related variables at DT in women. However, in postmenopausal women and, to a lesser extent, in older men, higher rates of cortical and trabecular bone loss were associated with lower levels of biologically-active sex steroids and with higher levels of follicle-stimulating hormone and bone turnover markers. Conclusions: The late onset of cortical bone loss is temporally associated with sex steroid deficiency. However, the early-onset, substantial trabecular bone loss in both sexes during sex steroid sufficiency is unexplained and indicates that current paradigms on the pathogenesis of osteoporosis are incomplete.

A population-based assessment of rates of bone loss at multiple skeletal sites: evidence for substantial trabecular bone loss in young adult women and men. Publishing Authors By Initials

BL Riggs,LJ Melton,RA Robb,JJ Camp,EJ Atkinson,L McDaniel,S Amin,PA Rouleau,S Khosla,BL Riggs,LJ Melton,RA Robb,JJ Camp,EJ Atkinson,L McDaniel,S Amin,PA Rouleau,S Khosla,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

A population-based assessment of rates of bone loss at multiple skeletal sites: evidence for substantial trabecular bone loss in young adult women and men. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of bone and mineral research : the officia

VOLUME: 23

Page Numbers: 205-14

Journal Abbreviation: J. Bone Miner. Res.

ISSN: 0884-0431

DAY: 16

MONTH: Feb

YEAR: 2008

A population-based assessment of rates of bone loss at multiple skeletal sites: evidence for substantial trabecular bone loss in young adult women and men. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8610640

A population-based assessment of rates of bone loss at multiple skeletal sites: evidence for substantial trabecular bone loss in young adult women and men. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: A population-based assessment of rates of bone loss at multiple skeletal sites: evidence for substantial trabecular bone loss in young adult women and men. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for A population-based assessment of rates of bone loss at multiple skeletal sites: evidence for substantial trabecular bone loss in young adult women and men.

AFFILIATION:

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Bone Miner Res

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

A population-based assessment of rates of bone loss at multiple skeletal sites: evidence for substantial trabecular bone loss in young adult women and men Related Publications

• A Cretaceous hoofed mammal from India.
• A population-based assessment of rates of bone loss at multiple skeletal sites: evidence for substantial trabecular bone loss in young adult women and men.
• A report of two 'traumatic encephaloceles'; an unrecognized entity.
• A scaleable manufacturing process for pro-EP-B2, a cysteine protease from barley indicated for celiac sprue.
• Assessment of gene regulation by bone morphogenetic protein 2 in human marrow stromal cells using gene array technology.
• Bioassay-guided evolution of glycosylated macrolide antibiotics in Escherichia coli.
• Characterization of circulating osteoblast lineage cells in humans.
• Combination enzyme therapy for gastric digestion of dietary gluten in patients with celiac sprue.
• Contribution of in vivo structural measurements and load/strength ratios to the determination of forearm fracture risk in postmenopausal women.
• DNA methylation profile at the DNMT3L promoter: a potential biomarker for cervical cancer.
• Does reduced skeletal loading account for age-related bone loss?
• Effects of loss of classical estrogen response element signaling on bone in male mice.
• Enhancement of dietary protein digestion by conjugated bile acids.
• High serum IGFBP-2 is predictive of increased bone turnover in aging men and women.
• High-trauma fractures and bone mineral density.
• Increased incidence of in-stent thrombosis related to cocaine use: case series and review of literature.
• Long-term fracture risk among women with proven endometriosis.
• MIB-1 immunolabeling: a valuable marker in prediction of benign recurring meningiomas.
• Osteoprotegerin production by human osteoblast lineage cells is stimulated by vitamin D, bone morphogenetic protein-2, and cytokines.
• Production of ansamycin polyketide precursors in Escherichia coli.
• Solution structure and proposed domain domain recognition interface of an acyl carrier protein domain from a modular polyketide synthase.
• Structural determinants of vertebral fracture risk.
• Structure-activity relationship analysis of the selective inhibition of transglutaminase 2 by dihydroisoxazoles.
• Structure-activity relationships of semisynthetic mumbaistatin analogs.
• Structure-based design of alpha-amido aldehyde containing gluten peptide analogues as modulators of HLA-DQ2 and transglutaminase 2.
• Structure-based dissociation of a type I polyketide synthase module.
• Substrate tolerance of module 6 of the epothilone synthetase.
• Synthesis and biological activity of novel pyranopyrones derived from engineered aromatic polyketides.
• The skeletal response to estrogen is impaired in female but not in male steroid receptor coactivator (SRC)-1 knock out mice.
• Transglutaminase 2 undergoes a large conformational change upon activation.