A polymorphism in New Zealand inbred mouse strains that inactivates phosphatidylcholine transfer protein.

A polymorphism in New Zealand inbred mouse strains that inactivates phosphatidylcholine transfer protein. Research Abstract Details 

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A polymorphism in New Zealand inbred mouse strains that inactivates phosphatidylcholine transfer protein. Abstract Text:

Huei-Ju Pan,Diana S Agate,Benjamin L King,Michele K Wu,Steven L Roderick,Edward H Leiter,David E Cohen,

New Zealand obese (NZO/HlLt) male mice develop polygenic diabetes and altered phosphatidylcholine metabolism. The gene encoding phosphatidylcholine transfer protein (PC-TP) is sited within the support interval for Nidd3, a recessive NZO-derived locus on Chromosome 11 identified by prior segregation analysis between NZO/HlLt and NON/Lt. Sequence analysis revealed that the NZO-derived PC-TP contained a non-synonymous point mutation that resulted in an Arg120His substitution, which was shared by the related NZB/BlNJ and NZW/LacJ mouse strains. Consistent with the structure-based predictions, functional studies demonstrated that Arg120His PC-TP was inactive, suggesting that this mutation contributes to the deficiencies in phosphatidylcholine metabolism observed in NZO mice.

A polymorphism in New Zealand inbred mouse strains that inactivates phosphatidylcholine transfer protein. Publishing Authors By Initials

HJ Pan,DS Agate,BL King,MK Wu,SL Roderick,EH Leiter,DE Cohen,

For similar biological phenomena, cell phenomena, and immunity: immunity: antibody specificity: species specificity research abstracts see: biological phenomena, cell phenomena, and immunity: immunity: antibody specificity: species specificity research

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A polymorphism in New Zealand inbred mouse strains that inactivates phosphatidylcholine transfer protein. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: FEBS letters

VOLUME: 580

Page Numbers: 5953-8

Journal Abbreviation: FEBS Lett.

ISSN: 0014-5793

DAY: 6

MONTH: 10

YEAR: 2006

A polymorphism in New Zealand inbred mouse strains that inactivates phosphatidylcholine transfer protein. Information

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LANGUAGE: eng

NlmUniqueID: 155157

A polymorphism in New Zealand inbred mouse strains that inactivates phosphatidylcholine transfer protein. Keywords Mesh Terms:

KEYWORDS: Species Specificity

MESH TERMS: genetics

Chemical & Substance for Abstract: A polymorphism in New Zealand inbred mouse strains that inactivates phosphatidylcholine transfer protein. Information

Substance Name: Phospholipid Transfer Proteins

Registry Number: 0

Grant and Affiliation Information for A polymorphism in New Zealand inbred mouse strains that inactivates phosphatidylcholine transfer protein.

AFFILIATION: Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.

Country: Netherlands

AGENCY: United States NIDDK

GRANT: DK56853

ACRONYM: DK

MEDLINETA: FEBS Lett

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