A plateau potential mediated by the activation of extrasynaptic NMDA receptors in rat hippocampal CA1 pyramidal neurons.

A plateau potential mediated by the activation of extrasynaptic NMDA receptors in rat hippocampal CA1 pyramidal neurons. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

A plateau potential mediated by the activation of extrasynaptic NMDA receptors in rat hippocampal CA1 pyramidal neurons. Abstract Text:

Hippocampal pyramidal neurons express various extrasynaptic glutamate receptors. When glutamate spillover was facilitated by blocking glutamate uptake and fast synaptic transmission was blocked by antagonists of AMPA- and NMDA-type glutamate receptors and an ionotropic GABA receptor blocker, repetitive synaptic stimulation evoked a persistent membrane depolarization that consisted of an early Ca(2+)-independent component and a late Ca(2+)-dependent component. The early component, which we refer to as a plateau potential, had a half-width of 770 +/- 160 ms and a steady peak level of -9.54 +/- 3.50 mV. It was accompanied by an increase in membrane conductance, the I-V relationship of which showed a peak at -19.91 +/- 2.18 mV and reversal of the current at -4.32 +/- 2.13 mV, and was suppressed by high concentration of an NMDA receptor (NMDAR) antagonist d-APV, or an NMDAR glycine-binding site antagonist 5,7-dCK. After blocking synaptically located NMDARs using MK801, the potential was still evoked synaptically when spillover was facilitated. A sustained depolarization was evoked by iontophoretic application of glutamate in the presence or absence of a glutamate uptake blocker. This potential was not affected by Na(+) or Ca(2+) channel blockers, but was suppressed by 5,7-dCK, leaving an unspecified depolarizing potential. Iontophoresis of NMDA evoked a sustained depolarization that was blocked by a high concentration of d-APV or 5,7-dCK. The I-V relationship of the current during this potential was similar to that obtained during the synaptically induced plateau potentials. These results show that CA1 pyramidal neurons generate plateau potentials mediated most likely by activation of extrasynaptic NMDARs.

A plateau potential mediated by the activation of extrasynaptic NMDA receptors in rat hippocampal CA1 pyramidal neurons. Publishing Authors By Initials

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

A plateau potential mediated by the activation of extrasynaptic NMDA receptors in rat hippocampal CA1 pyramidal neurons. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The European journal of neuroscience

VOLUME: 28

Page Numbers: 521-34

Journal Abbreviation: Eur. J. Neurosci.

ISSN: 1460-9568

DAY: 15

MONTH: Aug

YEAR: 2008

A plateau potential mediated by the activation of extrasynaptic NMDA receptors in rat hippocampal CA1 pyramidal neurons. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8918110

A plateau potential mediated by the activation of extrasynaptic NMDA receptors in rat hippocampal CA1 pyramidal neurons. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: A plateau potential mediated by the activation of extrasynaptic NMDA receptors in rat hippocampal CA1 pyramidal neurons. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for A plateau potential mediated by the activation of extrasynaptic NMDA receptors in rat hippocampal CA1 pyramidal neurons.

AFFILIATION: Laboratory of Cellular Neurobiology, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo 192-0392, Japan.

Country: France

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Eur J Neurosci

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

A plateau potential mediated by the activation of extrasynaptic NMDA receptors in rat hippocampal CA1 pyramidal neurons Related Publications

• A plateau potential mediated by the activation of extrasynaptic NMDA receptors in rat hippocampal CA1 pyramidal neurons.
• Alpha-CaMKII deficiency causes immature dentate gyrus, a novel candidate endophenotype of psychiatric disorders.
• Array-enhanced coherence resonance and phase synchronization in a two-dimensional array of excitable chemical oscillators.
• Combined preoperative embolization of the right portal vein and hepatic artery for hepatic resection in a high-risk patient.
• Dementia and Borna disease virus.
• Development of EOG-Based Communication System Controlled by Eight-Directional Eye Movements.
• Evaluation of the preset travel routes in a self-determination support system.
• Genetic polymorphisms of transforming growth factor beta-1 promoter and primary biliary cirrhosis in Japanese patients.
• Identification of Saccharomyces cerevisiae Tub1 alpha-tubulin as a potential target for NKH-7, a cytotoxic 1-naphthol derivative compound.
• Identification of Tup1 and Cyc8 mutations defective in the responses to osmotic stress.
• Inhibition of Ca2+-signal-dependent growth regulation by radicicol in budding yeast.
• Interferon-alpha 2b-induced thrombocytopenia is caused by inhibition of platelet production but not proliferation and endomitosis in human megakaryocytes.
• Involvement of calcineurin-dependent degradation of Yap1p in Ca2+-induced G2 cell-cycle regulation in Saccharomyces cerevisiae.
• Ionic strength and pH effects on the rates of reduction of spinach plastocyanin by ascorbate.
• Multislice CT study of pancreatic head arterial dominance.
• Pancreatoduodenectomy in which dissection of the efferent arteries of the head of the pancreas is performed first.
• Pneumatosis intestinalis and hepatic portal venous gas.
• Purification and properties of trehalase from rat intestinal mucosal cells.
• Structured neural network of medical diagnosis for hepatobiliary diseases.
• The effect of a novel, small non-peptidyl molecule butyzamide on human thrombopoietin receptor and megakaryopoiesis.
• The role of hepatectomy for patients with liver metastases of gastric cancer.
• [Experimental animal models of multiple myeloma]
• [Investigating genes-to-behaviors pathways in psychiatric diseases: an approach using a comprehensive behavioral test battery on genetically engineered mice]
• [Navigation surgery for pancreatic disease using multislice computed tomography]
• [The effects of thyrotropin-suppressive therapy in patients with well-differentiated thyroid carcinoma]