A plateau in pre-Alzheimer memory decline: evidence for compensatory mechanisms?

A plateau in pre-Alzheimer memory decline: evidence for compensatory mechanisms? Research Abstract Details 

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A plateau in pre-Alzheimer memory decline: evidence for compensatory mechanisms? Abstract Text:

G E Smith,V S Pankratz,S Negash,M M Machulda,R C Petersen,B F Boeve,D S Knopman,J A Lucas,T J Ferman,N Graff-Radford,R J Ivnik,

OBJECTIVE: To compare logistic and bilogistic models to describe the pattern of cognitive decline in the preclinical phase of Alzheimer disease (AD). METHODS: We conducted mixed effects modeling of Mayo Cognitive Factors Scores to determine the longitudinal pattern of cognitive decline in the period 10 years prior to and 5 years following a clinical diagnosis of AD. Our analysis included 199 people that eventually received a diagnosis of clinically probable AD. Participants had at least two neuropsychological evaluations including one before the evaluation at which they received the AD diagnosis. RESULTS: A bilogistic model, including terms for a plateau in the course of cognitive decline, better fit longitudinal memory scores than a simple logistic model. On average the plateau began about 4 years prior to the clinical diagnosis of AD and ended with a decline that probably contributed to the clinical diagnosis of AD. A similar plateau was not evident in four other cognitive domains. CONCLUSIONS: The current findings may support proposed compensatory hypotheses involving redundant memory systems, up-regulation of neurotransmitters, or recruitment of other neural networks.

A plateau in pre-Alzheimer memory decline: evidence for compensatory mechanisms? Publishing Authors By Initials

GE Smith,VS Pankratz,S Negash,MM Machulda,RC Petersen,BF Boeve,DS Knopman,JA Lucas,TJ Ferman,N Graff-Radford,RJ Ivnik,

For similar diagnosis: prognosis research abstracts see: diagnosis: prognosis research

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A plateau in pre-Alzheimer memory decline: evidence for compensatory mechanisms? Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Neurology

VOLUME: 69

Page Numbers: 133-9

Journal Abbreviation: Neurology

ISSN: 1526-632X

DAY: 10

MONTH: Jul

YEAR: 2007

A plateau in pre-Alzheimer memory decline: evidence for compensatory mechanisms? Information

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LANGUAGE: eng

NlmUniqueID: 401060

A plateau in pre-Alzheimer memory decline: evidence for compensatory mechanisms? Keywords Mesh Terms:

KEYWORDS: Prognosis

MESH TERMS: physiology

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Grant and Affiliation Information for A plateau in pre-Alzheimer memory decline: evidence for compensatory mechanisms?

AFFILIATION: Department of Psychiatry and Psychology, Mayo Clinic, Rochester, MN 55905, USA. smith.glenn@mayo.edu

Country: United States

AGENCY: United States NIA

GRANT: U01 AG06786

ACRONYM: AG

MEDLINETA: Neurology

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