A pilot study of adjunctive atomoxetine treatment to second-generation antipsychotics for cognitive impairment in schizophrenia.

A pilot study of adjunctive atomoxetine treatment to second-generation antipsychotics for cognitive impairment in schizophrenia. Research Abstract Details 

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A pilot study of adjunctive atomoxetine treatment to second-generation antipsychotics for cognitive impairment in schizophrenia. Abstract Text:

Joseph I Friedman,David Carpenter,Jing Lu,Jin Fan,Cheuk Y Tang,Leonard White,Michael Parrella,Stephanie Bowler,Zeinab Elbaz,Lauren Flanagan,Philip D Harvey,Joseph I Friedman,David Carpenter,Jing Lu,Jin Fan,Cheuk Y Tang,Leonard White,Michael Parrella,Stephanie Bowler,Zeinab Elbaz,Lauren Flanagan,Philip D Harvey,

Relationships between altered prefrontal cortical dopamine, norepinephrine, and some of the cognitive impairments of schizophrenia support an approach for pharmacological remediation of cognitive symptoms through manipulations of prefrontal cortical dopamine and norepinephrine. Atomoxetine, a selective norepinephrine reuptake inhibitor, produces a widespread increase in brain norepinephrine and a secondary and selective increase in prefrontal dopamine. Given this, we evaluated atomoxetine's cognitive effects in a pilot placebo-controlled trial in patients with schizophrenia. Moreover, a functional magnetic resonance imaging investigation was undertaken to assess the neural mechanisms underlying the cognitive effects of atomoxetine. Twenty participants with schizophrenia were randomized to treatment with placebo or atomoxetine 80 mg daily for an 8-week parallel-designed treatment trial. Cognitive performance was assessed with the Brief Assessment of Cognition in Schizophrenia. No significant cognitive improvement was associated with atomoxetine treatment. However, atomoxetine treatment was associated with significantly greater increases in working memory-related activation of the left dorsolateral prefrontal and left posterior cingulate cortices. The negative results of this study conflict with the effectiveness of amphetamine in enhancing the cognitive abilities of schizophrenic patients and may be related to the differential pattern of cortical activation and deactivation produced by amphetamine.

A pilot study of adjunctive atomoxetine treatment to second-generation antipsychotics for cognitive impairment in schizophrenia. Publishing Authors By Initials

JI Friedman,D Carpenter,J Lu,J Fan,CY Tang,L White,M Parrella,S Bowler,Z Elbaz,L Flanagan,PD Harvey,JI Friedman,D Carpenter,J Lu,J Fan,CY Tang,L White,M Parrella,S Bowler,Z Elbaz,L Flanagan,PD Harvey,

For similar behavioral disciplines and activities: schizophrenic psychology research abstracts see: behavioral disciplines and activities: schizophrenic psychology research

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A pilot study of adjunctive atomoxetine treatment to second-generation antipsychotics for cognitive impairment in schizophrenia. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of clinical psychopharmacology

VOLUME: 28

Page Numbers: 59-63

Journal Abbreviation:

ISSN: 0271-0749

DAY: 27

MONTH: Feb

YEAR: 2008

A pilot study of adjunctive atomoxetine treatment to second-generation antipsychotics for cognitive impairment in schizophrenia. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8109496

A pilot study of adjunctive atomoxetine treatment to second-generation antipsychotics for cognitive impairment in schizophrenia. Keywords Mesh Terms:

KEYWORDS: Schizophrenic Psychology

MESH TERMS: drug therapy

Chemical & Substance for Abstract: A pilot study of adjunctive atomoxetine treatment to second-generation antipsychotics for cognitive impairment in schizophrenia. Information

Substance Name: atomoxetine

Registry Number: 83015-26-3

Grant and Affiliation Information for A pilot study of adjunctive atomoxetine treatment to second-generation antipsychotics for cognitive impairment in schizophrenia.

AFFILIATION: Department of Psychiatry, Mount Sinai School of Medicine, New York, NY 10029, USA. jfriedman1@rcn.com

Country: United States

AGENCY: United States NCRR

GRANT: M01-RR-00071

ACRONYM: RR

MEDLINETA: J Clin Psychopharmacol

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