A pilot study evaluating the efficacy of topically applied niacin derivatives for treatment of female pattern alopecia.

A pilot study evaluating the efficacy of topically applied niacin derivatives for treatment of female pattern alopecia. Research Abstract Details 

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A pilot study evaluating the efficacy of topically applied niacin derivatives for treatment of female pattern alopecia. Abstract Text:

Zoe Diana Draelos,Elaine L Jacobson,Hyuntae Kim,Moonsun Kim,Myron K Jacobson,

Background Female pattern alopecia is a common dermatologic condition that manifests after puberty. The only approved drug treatment for this condition is 2% minoxidil for topical application. Aims This pilot study examined the effect of topical application of two niacin derivatives, octyl nicotinate and tetradecyl nicotinate, on hair fullness in female alopecia. Patients/methods Sixty female subjects with Ludwig types I-III female pattern hair loss were evaluated in a double-blinded, placebo-controlled (40 active, 20 placebo) design using standardized 35-mm photographic analyses for assessment of efficacy after 6 months of application. Results The niacin derivatives demonstrated a statistically significant increase in hair fullness (P = 0.04 compared to the placebo). Conclusion Whereas evaluation of hair growth in women is challenging, this 6-month pilot study demonstrated statistically significant increase in hair fullness on blinded 35-mm photographic analysis. Long-term topical application of nicotinic acid derivatives offers promise for providing benefit in female alopecia and warrants further study.

A pilot study evaluating the efficacy of topically applied niacin derivatives for treatment of female pattern alopecia. Publishing Authors By Initials

ZD Draelos,EL Jacobson,H Kim,M Kim,MK Jacobson,

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A pilot study evaluating the efficacy of topically applied niacin derivatives for treatment of female pattern alopecia. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of cosmetic dermatology

VOLUME: 4

Page Numbers: 258-61

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ISSN: 1473-2165

DAY: 15

MONTH: Dec

YEAR: 2005

A pilot study evaluating the efficacy of topically applied niacin derivatives for treatment of female pattern alopecia. Information

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LANGUAGE: eng

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Grant and Affiliation Information for A pilot study evaluating the efficacy of topically applied niacin derivatives for treatment of female pattern alopecia.

AFFILIATION: Department of Dermatology, Wake Forest University School of Medicine, NC.

Country: England

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MEDLINETA: J Cosmet Dermatol

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