A phased-array stimulator system for studying planar and curved cardiac activation wavefronts.

A phased-array stimulator system for studying planar and curved cardiac activation wavefronts. Research Abstract Details 

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A phased-array stimulator system for studying planar and curved cardiac activation wavefronts. Abstract Text:

Rashida A Abbas,Shien-Fong Lin,David Mashburn,Junkai Xu,John P Wikswo,

Wavefront propagation in cardiac tissue is affected greatly by the geometry of the wavefront. We describe a computer-controlled stimulator system that creates reproducible wavefronts of a predetermined shape and orientation for the investigation of the effects of wavefront geometry. We conducted demonstration experiments on isolated perfused rabbit hearts, which were stained with the voltage-sensitive dye, di-4-ANEPPS. The wavefronts were imaged using a laser and a charge-coupled device (CCD) camera. The stimulator and imaging systems have been used to characterize the relationship between wavefront velocity and fiber orientation. This approach has potential applications in investigating curvature effects, testing numerical models of cardiac tissue, and creating complex wavefronts using one-, two-, or three-dimensional electrode arrays.

A phased-array stimulator system for studying planar and curved cardiac activation wavefronts. Publishing Authors By Initials

RA Abbas,SF Lin,D Mashburn,J Xu,JP Wikswo,

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A phased-array stimulator system for studying planar and curved cardiac activation wavefronts. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: IEEE transactions on bio-medical engineering

VOLUME: 55

Page Numbers: 222-9

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ISSN: 0018-9294

DAY: 31

MONTH: Jan

YEAR: 2008

A phased-array stimulator system for studying planar and curved cardiac activation wavefronts. Information

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LANGUAGE: eng

NlmUniqueID: 12737

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Grant and Affiliation Information for A phased-array stimulator system for studying planar and curved cardiac activation wavefronts.

AFFILIATION: Department of Physics and Astronomy, Vanderbilt University, Division of Cardiovascular Medicine, Vanderbilt University Medical Center, Nashville, TN 37235, USA. abbasr@comcast.net

Country: United States

AGENCY: United States NHLBI

GRANT: R01-HL58241

ACRONYM: HL

MEDLINETA: IEEE Trans Biomed Eng

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