A phase II trial of modified FOLFOX as first-line chemotherapy in advanced colorectal cancer.

A phase II trial of modified FOLFOX as first-line chemotherapy in advanced colorectal cancer. Research Abstract Details 

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A phase II trial of modified FOLFOX as first-line chemotherapy in advanced colorectal cancer. Abstract Text:

Jian Ping Xiong,Ling Zhang,Lu Xing Zhong,Feng Qiu,Jun Xu,Qing Song Tao,Xiao Jun Xiang,Feng Yu,Xiao Mei Tang,

The objective was to evaluate the efficacy and toxicity of leucovorin plus 5-fluorouracil combined with oxaliplatin (modified FOLFOX regimen) every 2 weeks on previously untreated advanced colorectal cancer patients in the Chinese population. Fifty-one inpatients were enrolled to receive 85 mg/m oxaliplatin intravenously over a 2- h period on day 1, together with 400 mg/m2 leucovorin over 2- h, followed by a 46-h infusion of 5-fluorouracil at 2600 mg/m2 every 2 weeks. Treatment was given until progression or unmanageable toxicity ensued. In all, 51 patients received three or more oxaliplatin doses and a median of nine treatment cycles (range 3-16 cycles). Of the 51 eligible patients, two complete responses and 22 partial responses were observed for an overall response rate of 47.0% (95% confidence interval 35-64%). Median progression-free survival was 7.7 months (95% confidence interval 6.8-8.6) and median overall survival was 15.0 months (95% confidence interval 13.1-16.9). Toxicities were mild: five patients (9.8%) reported grade 3-4 neutropenia, 33 patients (64.8%) experienced grade 1-3 neurotoxicity and only six patients (11.8%) experienced grade 3 neurotoxicity. The leucovorin plus 5-fluorouracil combined with oxaliplatin (modified FOLFOX) regimen is active and well tolerated in patients with previously untreated advanced colorectal cancer in the Chinese population.

A phase II trial of modified FOLFOX as first-line chemotherapy in advanced colorectal cancer. Publishing Authors By Initials

JP Xiong,L Zhang,LX Zhong,F Qiu,J Xu,QS Tao,XJ Xiang,F Yu,XM Tang,

For similar organic chemicals: organometallic compounds: organoplatinum compounds research abstracts see: organic chemicals: organometallic compounds: organoplatinum compounds research

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A phase II trial of modified FOLFOX as first-line chemotherapy in advanced colorectal cancer. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Anti-cancer drugs

VOLUME: 18

Page Numbers: 1103-7

Journal Abbreviation: Anticancer Drugs

ISSN: 0959-4973

DAY: 30

MONTH: Oct

YEAR: 2007

A phase II trial of modified FOLFOX as first-line chemotherapy in advanced colorectal cancer. Information

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LANGUAGE: eng

NlmUniqueID: 9100823

A phase II trial of modified FOLFOX as first-line chemotherapy in advanced colorectal cancer. Keywords Mesh Terms:

KEYWORDS: Organoplatinum Compounds

MESH TERMS: therapeutic use

Chemical & Substance for Abstract: A phase II trial of modified FOLFOX as first-line chemotherapy in advanced colorectal cancer. Information

Substance Name: Leucovorin

Registry Number: 58-05-9

Grant and Affiliation Information for A phase II trial of modified FOLFOX as first-line chemotherapy in advanced colorectal cancer.

AFFILIATION: Department of Oncology, The First Affiliated Hospital, Nanchang University, Nanchang, PRC. jpxiong@medmail.com.cn

Country: England

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MEDLINETA: Anticancer Drugs

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