A peroxisome proliferator-activated receptor gamma antagonist induces vimentin cleavage and inhibits invasion in high-grade hepatocellular carcinoma.

A peroxisome proliferator-activated receptor gamma antagonist induces vimentin cleavage and inhibits invasion in high-grade hepatocellular carcinoma. Research Abstract Details 

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A peroxisome proliferator-activated receptor gamma antagonist induces vimentin cleavage and inhibits invasion in high-grade hepatocellular carcinoma. Abstract Text:

Kyung Ryoul Kim,Ha Na Choi,Ho Jin Lee,Hyun A Baek,Ho Sung Park,Kyu Yun Jang,Myoung Ja Chung,Woo Sung Moon,

Increased expression of vimentin in carcinomas correlates with parameters of malignant potential such as tumor grade and tumor metastasis. Peroxisome proliferator-activated receptor gamma (PPARgamma) has been intensively evaluated as a potential target for the inhibition of cell growth and metastasis in cancer cells. In the present study, we examined whether PPARgamma is a possible target molecule for the prevention of cell growth and invasion by treatment with agonists (troglitazone, rosiglitazone) and antagonists (T0070907, GW9662) in four different hepatocellular carcinoma (HCC) cell lines. We also evaluated the effects of the PPARgamma agonists and antagonists on tumor cell migration and invasion. The expression level of PPARgamma protein was higher in the sarcomatoid SH-J1 and poorly differentiated HLE cell lines than that in the well-differentiated HCC cell lines (HepG2 and Huh-7). Expression of vimentin was high in the SH-J1 HCC cell line and minimally detected in the HLE cell line. Treatment with low doses of the PPARgamma antagonists inhibited cell growth and colony formation of all four of the HCC cell lines. Vimentin in the high-grade HCC cells was cleaved by the treatment with the PPARgamma antagonists. Furthermore, treatment with the PPARgamma antagonists also strongly inhibited migration and invasion of the SH-J1 and HLE cells. However, treatment with low doses of the agonists had no effect on vimentin expression, migration, and invasion of the high-grade HCC cells but cell growth was inhibited by treatment with high concentrations of the agonists. Our results indicate that treatment with a PPARgamma antagonist may prevent cell growth and invasion of high-grade HCC cells. Our findings also suggest that PPARgamma antagonists inhibit cell growth and invasion through vimentin disarrangement in high-grade HCC.

A peroxisome proliferator-activated receptor gamma antagonist induces vimentin cleavage and inhibits invasion in high-grade hepatocellular carcinoma. Publishing Authors By Initials

KR Kim,HN Choi,HJ Lee,HA Baek,HS Park,KY Jang,MJ Chung,WS Moon,

For similar macromolecular substances: polymers: biopolymers: intermediate filament proteins: vimentin research abstracts see: macromolecular substances: polymers: biopolymers: intermediate filament proteins: vimentin research

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A peroxisome proliferator-activated receptor gamma antagonist induces vimentin cleavage and inhibits invasion in high-grade hepatocellular carcinoma. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Oncology reports

VOLUME: 18

Page Numbers: 825-32

Journal Abbreviation: Oncol. Rep.

ISSN: 1021-335X

DAY: 19

MONTH: Oct

YEAR: 2007

A peroxisome proliferator-activated receptor gamma antagonist induces vimentin cleavage and inhibits invasion in high-grade hepatocellular carcinoma. Information

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LANGUAGE: eng

NlmUniqueID: 9422756

A peroxisome proliferator-activated receptor gamma antagonist induces vimentin cleavage and inhibits invasion in high-grade hepatocellular carcinoma. Keywords Mesh Terms:

KEYWORDS: Vimentin

MESH TERMS: metabolism

Chemical & Substance for Abstract: A peroxisome proliferator-activated receptor gamma antagonist induces vimentin cleavage and inhibits invasion in high-grade hepatocellular carcinoma. Information

Substance Name: troglitazone

Registry Number: 97322-87-7

Grant and Affiliation Information for A peroxisome proliferator-activated receptor gamma antagonist induces vimentin cleavage and inhibits invasion in high-grade hepatocellular carcinoma.

AFFILIATION: Department of Pathology, Institute for Medical Sciences and the Center for Healthcare Technology Development, Chonbuk National University, Medical School, Jeonju 560-180, Korea.

Country: Greece

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MEDLINETA: Oncol Rep

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