A peptide conjugate of vitamin E succinate targets breast cancer cells with high ErbB2 expression.

A peptide conjugate of vitamin E succinate targets breast cancer cells with high ErbB2 expression. Research Abstract Details 

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A peptide conjugate of vitamin E succinate targets breast cancer cells with high ErbB2 expression. Abstract Text:

Xiu-Fang Wang,Marc Birringer,Lan-Feng Dong,Pavel Veprek,Pauline Low,Emma Swettenham,Marina Stantic,Lin-Hong Yuan,Renata Zobalova,Kun Wu,Miroslav Ledvina,Stephen J Ralph,Jiri Neuzil,

Overexpression of erbB2 is associated with resistance to apoptosis. We explored whether high level of erbB2 expression by cancer cells allows their targeting using an erbB2-binding peptide (LTVSPWY) attached to the proapoptotic alpha-tocopheryl succinate (alpha-TOS). Treating erbB2-low or erbB2-high cells with alpha-TOS induced similar levels of apoptosis, whereas alpha-TOS-LTVSPWY induced greater levels of apoptosis in erbB2-high cells. alpha-TOS rapidly accumulated in erbB2-high cells exposed to alpha-TOS-LTVSPWY. The extent of apoptosis induced in erbB2-high cells by alpha-TOS-LTVSPWY was suppressed by erbB2 RNA interference as well as by inhibition of either endocytotic or lysosomal function. alpha-TOS-LTVSPWY reduced erbB2-high breast carcinomas in FVB/N c-neu transgenic mice. We conclude that a conjugate of a peptide targeting alpha-TOS to erbB2-overexpressing cancer cells induces rapid apoptosis and efficiently suppresses erbB2-positive breast tumors.

A peptide conjugate of vitamin E succinate targets breast cancer cells with high ErbB2 expression. Publishing Authors By Initials

XF Wang,M Birringer,LF Dong,P Veprek,P Low,E Swettenham,M Stantic,LH Yuan,R Zobalova,K Wu,M Ledvina,SJ Ralph,J Neuzil,

For similar heterocyclic compounds: heterocyclic compounds, 2-ring: benzopyrans: vitamin e research abstracts see: heterocyclic compounds: heterocyclic compounds, 2-ring: benzopyrans: vitamin e research

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A peptide conjugate of vitamin E succinate targets breast cancer cells with high ErbB2 expression. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Cancer research

VOLUME: 67

Page Numbers: 3337-44

Journal Abbreviation:

ISSN: 0008-5472

DAY: 1

MONTH: Apr

YEAR: 2007

A peptide conjugate of vitamin E succinate targets breast cancer cells with high ErbB2 expression. Information

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LANGUAGE: eng

NlmUniqueID: 2984705

A peptide conjugate of vitamin E succinate targets breast cancer cells with high ErbB2 expression. Keywords Mesh Terms:

KEYWORDS: Vitamin E

MESH TERMS: pharmacokinetics

Chemical & Substance for Abstract: A peptide conjugate of vitamin E succinate targets breast cancer cells with high ErbB2 expression. Information

Substance Name: Receptor, erbB-2

Registry Number: EC 2.7.1.112

Grant and Affiliation Information for A peptide conjugate of vitamin E succinate targets breast cancer cells with high ErbB2 expression.

AFFILIATION: Apoptosis Research Group and Genomics Research Centre, School of Medical Science, Griffith University, Southport, Queensland, Australia.

Country: United States

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MEDLINETA: Cancer Res

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