A paradox: Insulin inhibits expression and secretion of resistin which induces insulin resistance.

A paradox: Insulin inhibits expression and secretion of resistin which induces insulin resistance. Research Abstract Details 

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A paradox: Insulin inhibits expression and secretion of resistin which induces insulin resistance. Abstract Text:

Feng Liu,Hong Qi Fan,Jie Qiu,Bin Wang,Min Zhang,Nan Gu,Chun Mei Zhang,Li Fei,Xiao-Qing Pan,Mei Guo,Rong Hua Chen,Xi Rong Guo,Feng Liu,Hong-Qi Fan,Jie Qiu,Bin Wang,Min Zhang,Nan Gu,Chun-Mei Zhang,Li Fei,Xiao-Qing Pan,Mei Guo,Rong-Hua Chen,Xi-Rong Guo,

AIM: To confirm whether insulin regulates resistin expression and secretion during differentiation of 3T3-L1 preadipocytes and the relationship of resistin with insulin resistance both in vivo and in vitro. METHODS: Supernatant resistin was measured during differentiation of 3T3-L1 preadipocytes. L6 rat myoblasts and hepatoma cell line H4IIE were used to confirm the cellular function of resistin. Diet-induced obese rats were used as an insulin resistance model to study the relationship of resistin with insulin resistance. RESULTS: Resistin expression and secretion were enhanced during differentiation 3T3-L1 preadipocytes. This cellular differentiation stimulated resistin expression and secretion, but was suppressed by insulin. Resistin also induced insulin resistance in H4IIE hepatocytes and L6 myoblasts. In diet-induced obese rats, serum resistin levels were negatively correlated with insulin sensitivity, but not with serum insulin. CONCLUSION: Insulin can inhibit resistin expression and secretion in vitro, but insulin is not a major regulator of resistin in vivo. Fat tissue mass affects insulin sensitivity by altering the expression and secretion of resistin.

A paradox: Insulin inhibits expression and secretion of resistin which induces insulin resistance. Publishing Authors By Initials

F Liu,HQ Fan,J Qiu,B Wang,M Zhang,N Gu,CM Zhang,L Fei,XQ Pan,M Guo,RH Chen,XR Guo,F Liu,HQ Fan,J Qiu,B Wang,M Zhang,N Gu,CM Zhang,L Fei,XQ Pan,M Guo,RH Chen,XR Guo,

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A paradox: Insulin inhibits expression and secretion of resistin which induces insulin resistance. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: World journal of gastroenterology : WJG

VOLUME: 14

Page Numbers: 95-100

Journal Abbreviation: World J. Gastroenterol.

ISSN: 1007-9327

DAY: 7

MONTH: Jan

YEAR: 2008

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LANGUAGE: eng

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AFFILIATION: Institute of Pediatrics of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China. xrguo@njmu.edu.cn.

Country: China

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MEDLINETA: World J Gastroenterol

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