A p53-type response element in the GDF15 promoter confers high specificity for p53 activation.

A p53-type response element in the GDF15 promoter confers high specificity for p53 activation. Research Abstract Details 

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A p53-type response element in the GDF15 promoter confers high specificity for p53 activation. Abstract Text:

Motonobu Osada,Hannah Lui Park,Min Joo Park,Jun-Wei Liu,Guojun Wu,Barry Trink,David Sidransky,Motonobu Osada,Hannah Lui Park,Min Joo Park,Jun-Wei Liu,Guojun Wu,Barry Trink,David Sidransky,

GDF15 is a transcriptional target gene for p53 and its family members, p63 and p73. Its promoter region contains two p53-type response elements, RE1 and RE2, and RE2 confers p53-specific transactivation. RE2 contains several mismatches from the canonical p53 response element (RRRCWWGYYY). Two mismatches in the RRR span and T base of the RE2 core sequence in the most 3' quarter-site are critical for inhibiting the binding affinity to p63 and p73 and corresponding promoter activity. Our results strongly suggest that differential DNA-binding affinities between p53 family member proteins act, at least in part, to confer specific target gene activation.

A p53-type response element in the GDF15 promoter confers high specificity for p53 activation. Publishing Authors By Initials

M Osada,HL Park,MJ Park,JW Liu,G Wu,B Trink,D Sidransky,M Osada,HL Park,MJ Park,JW Liu,G Wu,B Trink,D Sidransky,

For similar proteins: neoplasm proteins: tumor suppressor proteins research abstracts see: proteins: neoplasm proteins: tumor suppressor proteins research

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A p53-type response element in the GDF15 promoter confers high specificity for p53 activation. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Biochemical and biophysical research communication

VOLUME: 354

Page Numbers: 913-8

Journal Abbreviation: Biochem. Biophys. Res. Commun.

ISSN: 0006-291X

DAY: 25

MONTH: 01

YEAR: 2007

A p53-type response element in the GDF15 promoter confers high specificity for p53 activation. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 372516

A p53-type response element in the GDF15 promoter confers high specificity for p53 activation. Keywords Mesh Terms:

KEYWORDS: Tumor Suppressor Proteins

MESH TERMS: metabolism

Chemical & Substance for Abstract: A p53-type response element in the GDF15 promoter confers high specificity for p53 activation. Information

Substance Name: tumor suppressor protein p73

Registry Number: 0

Grant and Affiliation Information for A p53-type response element in the GDF15 promoter confers high specificity for p53 activation.

AFFILIATION: Department of Otolaryngology, Head and Neck Cancer Research Division, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Country: United States

AGENCY: United States NIDCR

GRANT: R01 DE013561-06

ACRONYM: DE

MEDLINETA: Biochem Biophys Res Commun

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