A novel t(8;18)(q13;q21) in acute monocytic leukemia evolving from constitutional trisomy 8 mosaicism.

A novel t(8;18)(q13;q21) in acute monocytic leukemia evolving from constitutional trisomy 8 mosaicism. Research Abstract Details 

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A novel t(8;18)(q13;q21) in acute monocytic leukemia evolving from constitutional trisomy 8 mosaicism. Abstract Text:

Katsuya Yamamoto,Atsuo Okamura,Hiroki Kawano,Yoshio Katayama,Manabu Shimoyama,Toshimitsu Matsui,

Constitutional trisomy 8 mosaicism (CT8M) has been considered to be the first mutation in multistep carcinogenesis. We describe the case of a 38-year-old woman with a normal phenotype who developed to acute monocytic leukemia with a novel t(8;18)(q13;q21). Chromosome analysis and spectral karyotyping showed 47,XX,+8,t(8;18)(q13;q21)[20]. Fluorescence in situ hybridization (FISH) demonstrated that the breakpoint at 18q21 was centromeric to the MALT1 and BCL2 genes. FISH also revealed that trisomy 8 was detected in buccal mucosa cells, indicating that trisomy 8 was a constitutional abnormality. These results suggest that t(8;18)(q13;q21) had a crucial role in the development of leukemia as the second mutation following CT8M.

A novel t(8;18)(q13;q21) in acute monocytic leukemia evolving from constitutional trisomy 8 mosaicism. Publishing Authors By Initials

K Yamamoto,A Okamura,H Kawano,Y Katayama,M Shimoyama,T Matsui,

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A novel t(8;18)(q13;q21) in acute monocytic leukemia evolving from constitutional trisomy 8 mosaicism. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Cancer genetics and cytogenetics

VOLUME: 176

Page Numbers: 144-9

Journal Abbreviation: Cancer Genet. Cytogenet.

ISSN: 0165-4608

DAY: 15

MONTH: Jul

YEAR: 2007

A novel t(8;18)(q13;q21) in acute monocytic leukemia evolving from constitutional trisomy 8 mosaicism. Information

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LANGUAGE: eng

NlmUniqueID: 7909240

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Grant and Affiliation Information for A novel t(8;18)(q13;q21) in acute monocytic leukemia evolving from constitutional trisomy 8 mosaicism.

AFFILIATION: Hematology/Oncology, Department of Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan.

Country: United States

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MEDLINETA: Cancer Genet Cytogenet

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