A novel subtype of Creutzfeldt-Jakob disease characterized by a small 6 kDa PrP fragment.

A novel subtype of Creutzfeldt-Jakob disease characterized by a small 6 kDa PrP fragment. Research Abstract Details 

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A novel subtype of Creutzfeldt-Jakob disease characterized by a small 6 kDa PrP fragment. Abstract Text:

Bjarne Krebs,Benedikt Bader,Juliane Klehmet,Eva Grasbon-Frodl,Wolfgang H Oertel,Inga Zerr,Sarah Stricker,Rolf Zschenderlein,Hans A Kretzschmar,

We report on a novel subtype of Creutzfeldt-Jakob disease with a single proteinase K-resistant prion protein fragment of about 6 kDa in Western blots of brain homogenates. Clinically this patient showed a progressive spastic disorder and dementia over 3 years. No mutation of the prion protein gene was found. Since this patient had received a blood transfusion, an iatrogenic cause, albeit unlikely, cannot be ruled out. Future studies will have to be attentive to small prion protein fragments, which may cause or be associated with unusual clinical disease that might possibly only be diagnosed by immunoblotting of brain homogenates.

A novel subtype of Creutzfeldt-Jakob disease characterized by a small 6 kDa PrP fragment. Publishing Authors By Initials

B Krebs,B Bader,J Klehmet,E Grasbon-Frodl,WH Oertel,I Zerr,S Stricker,R Zschenderlein,HA Kretzschmar,

For similar proteins: prions research abstracts see: proteins: prions research

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A novel subtype of Creutzfeldt-Jakob disease characterized by a small 6 kDa PrP fragment. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Acta neuropathologica

VOLUME: 114

Page Numbers: 195-9

Journal Abbreviation: Acta Neuropathol.

ISSN: 0001-6322

DAY: 19

MONTH: 06

YEAR: 2007

A novel subtype of Creutzfeldt-Jakob disease characterized by a small 6 kDa PrP fragment. Information

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LANGUAGE: eng

NlmUniqueID: 412041

A novel subtype of Creutzfeldt-Jakob disease characterized by a small 6 kDa PrP fragment. Keywords Mesh Terms:

KEYWORDS: Prions

MESH TERMS: genetics

Chemical & Substance for Abstract: A novel subtype of Creutzfeldt-Jakob disease characterized by a small 6 kDa PrP fragment. Information

Substance Name: Prions

Registry Number: 0

Grant and Affiliation Information for A novel subtype of Creutzfeldt-Jakob disease characterized by a small 6 kDa PrP fragment.

AFFILIATION: Center for Neuropathology and Prion Research, Ludwig-Maximilians-Universität München, National Reference Center for Transmissible Spongiform Encephalopathies, Feodor-Lynen-Str. 23, 81377, Munich, Germany.

Country: Germany

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MEDLINETA: Acta Neuropathol

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