A novel single-nucleotide polymorphism in the lactoferrin gene is associated with susceptibility to diarrhea in North American travelers to Mexico.

A novel single-nucleotide polymorphism in the lactoferrin gene is associated with susceptibility to diarrhea in North American travelers to Mexico. Research Abstract Details 

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A novel single-nucleotide polymorphism in the lactoferrin gene is associated with susceptibility to diarrhea in North American travelers to Mexico. Abstract Text:

Jamal A Mohamed,Herbert L DuPont,Zhi Dong Jiang,Jaime Belkind-Gerson,Jose Flores Figueroa,Lisa Y Armitige,An Tsai,Parvathy Nair,Francisco J Martinez-Sandoval,Dong-chuan Guo,Patricia Hayes,Pablo C Okhuysen,

BACKGROUND: Diarrhea affects 40%-60% of travelers from industrialized nations who visit developing countries and is due to bacterial, viral, and parasitic agents. Lactoferrin is bactericidal to enteric pathogens, modulates the intestinal immune response, and is excreted in stool in response to infection with intestinal organisms. We investigated the impact that selected single-nucleotide polymorphisms (SNPs) in the human lactoferrin gene have on susceptibility to traveler's diarrhea. METHODS: Adults who had recently arrived in Mexico were studied prospectively for the occurrence and causal agent(s) of traveler's diarrhea, and genotyping was performed for 9 distinct lactoferrin SNPs. RESULTS: Of the 9 SNPs studied, only 1 SNP (located in exon 15) was associated with traveler's diarrhea (P=.004). When compared with healthy travelers, and after adjustment for known risk factors for traveler's diarrhea (such as age and duration and season of travel), subjects with the T/T genotype in amino acid position 632 were more likely to develop traveler's diarrhea (67% vs. 33%; relative risk [RR], 1.4; 95% CI, 1.2-1.7; P<.001), to have diarrhea with a pathogen identified (RR, 1.3; 95% CI, 1.1-1.6; P=.03), and to have a marker of intestinal inflammation in stool specimens (blood, mucus, or white blood cells; 52% vs. 38%; P=.036). The association was also significant when norovirus was not identified in stool samples (RR, 1.34; 95% CI, 1.06-1.34; P=.01). CONCLUSIONS: The T/T genotype in position codon 632 of the lactoferrin gene is associated with susceptibility to diarrhea in North Americans traveling to Mexico.

A novel single-nucleotide polymorphism in the lactoferrin gene is associated with susceptibility to diarrhea in North American travelers to Mexico. Publishing Authors By Initials

JA Mohamed,HL DuPont,ZD Jiang,J Belkind-Gerson,JF Figueroa,LY Armitige,A Tsai,P Nair,FJ Martinez-Sandoval,DC Guo,P Hayes,PC Okhuysen,

For similar human activities: travel research abstracts see: human activities: travel research

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A novel single-nucleotide polymorphism in the lactoferrin gene is associated with susceptibility to diarrhea in North American travelers to Mexico. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Clinical infectious diseases : an official publica

VOLUME: 44

Page Numbers: 945-52

Journal Abbreviation: Clin. Infect. Dis.

ISSN: 1537-6591

DAY: 20

MONTH: 02

YEAR: 2007

A novel single-nucleotide polymorphism in the lactoferrin gene is associated with susceptibility to diarrhea in North American travelers to Mexico. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9203213

A novel single-nucleotide polymorphism in the lactoferrin gene is associated with susceptibility to diarrhea in North American travelers to Mexico. Keywords Mesh Terms:

KEYWORDS: Travel

MESH TERMS: epidemiology

Chemical & Substance for Abstract: A novel single-nucleotide polymorphism in the lactoferrin gene is associated with susceptibility to diarrhea in North American travelers to Mexico. Information

Substance Name: Lactoferrin

Registry Number: 0

Grant and Affiliation Information for A novel single-nucleotide polymorphism in the lactoferrin gene is associated with susceptibility to diarrhea in North American travelers to Mexico.

AFFILIATION: Division of Infectious Diseases, The University of Texas Medical School, Houston, TX 77030, USA.

Country: United States

AGENCY: United States PHS

GRANT: ULIRR024148

ACRONYM: AI

MEDLINETA: Clin Infect Dis

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