A novel role for the Aurora B kinase in epigenetic marking of silent chromatin in differentiated postmitotic cells.

A novel role for the Aurora B kinase in epigenetic marking of silent chromatin in differentiated postmitotic cells. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

A novel role for the Aurora B kinase in epigenetic marking of silent chromatin in differentiated postmitotic cells. Abstract Text:

Pierangela Sabbattini,Claudia Canzonetta,Marcela Sjoberg,Svetlana Nikic,Andrew Georgiou,Geoffrey Kemball-Cook,Holger W Auner,Niall Dillon,Pierangela Sabbattini,Claudia Canzonetta,Marcela Sjoberg,Svetlana Nikic,Andrew Georgiou,Geoffrey Kemball-Cook,Holger W Auner,Niall Dillon,

Combinatorial modifications of the core histones have the potential to fine-tune the epigenetic regulation of chromatin states. The Aurora B kinase is responsible for generating the double histone H3 modification tri-methylated K9/phosphorylated S10 (H3K9me3/S10ph), which has been implicated in chromosome condensation during mitosis. In this study, we have identified a novel role for Aurora B in epigenetic marking of silent chromatin during cell differentiation. We find that phosphorylation of H3 S10 by Aurora B generates high levels of the double H3K9me3/S10ph modification in differentiated postmitotic cells and also results in delocalisation of HP1beta away from heterochromatin in terminally differentiated plasma cells. Microarray analysis of the H3K9me3/S10ph modification shows a striking increase in the modification across repressed genes during differentiation of mesenchymal stem cells. Our results provide evidence that the Aurora B kinase has a role in marking silent chromatin independently of the cell cycle and suggest that targeting of Aurora B-mediated phosphorylation of H3 S10 to repressed genes could be a mechanism for epigenetic silencing of gene expression.

A novel role for the Aurora B kinase in epigenetic marking of silent chromatin in differentiated postmitotic cells. Publishing Authors By Initials

P Sabbattini,C Canzonetta,M Sjoberg,S Nikic,A Georgiou,G Kemball-Cook,HW Auner,N Dillon,P Sabbattini,C Canzonetta,M Sjoberg,S Nikic,A Georgiou,G Kemball-Cook,HW Auner,N Dillon,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

A novel role for the Aurora B kinase in epigenetic marking of silent chromatin in differentiated postmitotic cells. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The EMBO journal

VOLUME: 26

Page Numbers: 4657-69

Journal Abbreviation:

ISSN: 1460-2075

DAY: 18

MONTH: 10

YEAR: 2007

A novel role for the Aurora B kinase in epigenetic marking of silent chromatin in differentiated postmitotic cells. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8208664

A novel role for the Aurora B kinase in epigenetic marking of silent chromatin in differentiated postmitotic cells. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: A novel role for the Aurora B kinase in epigenetic marking of silent chromatin in differentiated postmitotic cells. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for A novel role for the Aurora B kinase in epigenetic marking of silent chromatin in differentiated postmitotic cells.

AFFILIATION: Gene Regulation and Chromatin Group, MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, London, UK. pierangela.sabbattini@csc.mrc.ac.uk <pierangela.sabbattini@csc.mrc.ac.uk>

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: EMBO J

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

A novel role for the Aurora B kinase in epigenetic marking of silent chromatin in differentiated postmitotic cells Related Publications

• A novel role for the Aurora B kinase in epigenetic marking of silent chromatin in differentiated postmitotic cells.
• Anesthetic problems in general practice.
• Cerebellar ischemia as a complication of myocardial infarction during treatment with acenocoumarin.
• Completely minimally invasive approach to restorative total proctocolectomy with j-pouch construction in children.
• Dehydroepiandrosterone protects vascular endothelial cells against apoptosis through a Galphai protein-dependent activation of phosphatidylinositol 3-kinase/Akt and regulation of antiapoptotic Bcl-2 expression.
• Differentiation of glioblastoma multiforme and single brain metastasis by peak height and percentage of signal intensity recovery derived from dynamic susceptibility-weighted contrast-enhanced perfusion MR imaging.
• Effect of low-frequency gain and venting effects on the benefit derived from directionality and noise reduction in hearing aids.
• Effects of breed, feeding system, and parity on udder health and milking characteristics.
• Experience reigns.
• Framework and prototype for a secure XML-based electronic health records system.
• Genetics of grass dry matter intake, energy balance, and digestibility in grazing irish dairy cows.
• How OTs and PTs can help stroke patients recover.
• Hypertension in children.
• Intrathecal gadolinium: its time has come?
• Microbial biofilms in the human gastrointestinal tract.
• Neuropsychological correlates of vocabulary, reading, and working memory in deaf children with cochlear implants.
• Oxindolealanine in age-related human cataracts.
• P30.16: Accuracy of ultrasound in predicting pathologic marginal sinus of the placenta.
• P37.10: Imaging the fetal septum pellucidum and fornix at 16 to 37 weeks of gestation.
• Production of cellulases and hemicellulases by Penicillium echinulatum grown on pretreated sugar cane bagasse and wheat bran in solid-state fermentation.
• Removal of cysteinylation from an unpaired sulfhydryl in the variable region of a recombinant monoclonal IgG1 antibody improves homogeneity, stability, and biological activity.
• Small molecule complementarity as a source of novel pharmaceutical agents and combination therapies.
• Spontaneous mutation at the mtr locus of Neurospora: the spectrum of mutant types.
• Stoichiometric analysis of the TM2 6' phenylalanine mutation on desensitization in alpha1beta2 and alpha1beta2gamma2 GABA(A) receptors.
• Studies of the eye with radiosodium autographs.
• Survival of rats after temporary complete renal ischemia.
• The combined effect of cyclopropane and the depolarizers on isolated human muscle.
• The effects of moderate neonatal ethanol exposure on eyeblink conditioning and deep cerebellar nuclei neuron numbers in the rat.
• Young Australians and alcohol: the acceptabllity of ready-to-drink (RTD) alcoholic beverages among 12-30-year-olds.
• [Not Available.]