A novel role for DNA mismatch repair and the autophagic processing of chemotherapy drugs in human tumor cells.

A novel role for DNA mismatch repair and the autophagic processing of chemotherapy drugs in human tumor cells. Research Abstract Details 

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A novel role for DNA mismatch repair and the autophagic processing of chemotherapy drugs in human tumor cells. Abstract Text:

Xuehuo Zeng,Tao Yan,Jane E Schupp,Yuji Seo,Timothy J Kinsella,

DNA Mismatch repair (MMR) maintains genome integrity by correcting DNA replication errors and blocking homologous recombination between divergent DNA sequences. The MMR system also activates both checkpoint and apoptotic responses following certain types of DNA damage. In a recent study, we describe a novel role for MMR in mediating an autophagic response to 6?thioguanine (6-TG), a DNA modifying chemical. Our results show that MMR proteins (MLH1 or MSH2) are required for signaling to the autophagic pathway after exposure to 6-TG. Using PFT-alpha, a p53 inhibitor, and shRNA-mediated silencing of p53 expression, we also show that p53 plays an essential role in the autophagic pathway downstream of the MMR system. This study suggests a novel function of MMR in mediating autophagy following chemical (6-TG) DNA mismatch damage through p53 activation. Here, we present the model and the clinical implications of the role of MMR in autophagy.

A novel role for DNA mismatch repair and the autophagic processing of chemotherapy drugs in human tumor cells. Publishing Authors By Initials

X Zeng,T Yan,JE Schupp,Y Seo,TJ Kinsella,

For similar proteins: dna-binding proteins: tumor suppressor protein p53 research abstracts see: proteins: dna-binding proteins: tumor suppressor protein p53 research

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A novel role for DNA mismatch repair and the autophagic processing of chemotherapy drugs in human tumor cells. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Autophagy

VOLUME: 3

Page Numbers: 368-70

Journal Abbreviation: Autophagy

ISSN: 1554-8627

DAY: 29

MONTH: 07

YEAR: 2007

A novel role for DNA mismatch repair and the autophagic processing of chemotherapy drugs in human tumor cells. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 101265188

A novel role for DNA mismatch repair and the autophagic processing of chemotherapy drugs in human tumor cells. Keywords Mesh Terms:

KEYWORDS: Tumor Suppressor Protein p53

MESH TERMS: metabolism

Chemical & Substance for Abstract: A novel role for DNA mismatch repair and the autophagic processing of chemotherapy drugs in human tumor cells. Information

Substance Name: MutS Homolog 2 Protein

Registry Number: EC 3.6.1.3

Grant and Affiliation Information for A novel role for DNA mismatch repair and the autophagic processing of chemotherapy drugs in human tumor cells.

AFFILIATION: Department of Radiation Oncology, Case Western Reserve University, University Hospitals Case Medical Center, Cleveland, Ohio 44106-6068, USA.

Country: United States

AGENCY: United States NCI

GRANT: CA112963

ACRONYM: CA

MEDLINETA: Autophagy

REFSOURCE: Clin Cancer Res. 2007 Feb 15;13(4):1315-

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